Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape

The global pandemic of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), places a heavy burden on global public health. Four SARS-CoV-2 variants of concern including B.1.1.7, B.1.351, B.1.617.2, and P.1, and two variants of interest incl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fuxing Lou, Maochen Li, Zehan Pang, Lin Jiang, Lin Guan, Lili Tian, Jiaming Hu, Junfen Fan, Huahao Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	SARS-CoV-2 variants immune escape vaccine neutralizing antibody variants of interest variants of concern Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5a4c978ca4124e15b649e837177f3176
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a4c978ca4124e15b649e837177f3176
record_format	dspace
spelling	oai:doaj.org-article:5a4c978ca4124e15b649e837177f31762021-11-05T12:43:26ZUnderstanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape1664-322410.3389/fimmu.2021.744242https://doaj.org/article/5a4c978ca4124e15b649e837177f31762021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.744242/fullhttps://doaj.org/toc/1664-3224The global pandemic of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), places a heavy burden on global public health. Four SARS-CoV-2 variants of concern including B.1.1.7, B.1.351, B.1.617.2, and P.1, and two variants of interest including C.37 and B.1.621 have been reported to have potential immune escape, and one or more mutations endow them with worrisome epidemiologic, immunologic, or pathogenic characteristics. This review introduces the latest research progress on SARS-CoV-2 variants of interest and concern, key mutation sites, and their effects on virus infectivity, mortality, and immune escape. Moreover, we compared the effects of various clinical SARS-CoV-2 vaccines and convalescent sera on epidemic variants, and evaluated the neutralizing capability of several antibodies on epidemic variants. In the end, SARS-CoV-2 evolution strategies in different transmission stages, the impact of different vaccination strategies on SARS-CoV-2 immune escape, antibody therapy strategies and COVID-19 epidemic control prospects are discussed. This review will provide a systematic and comprehensive understanding of the secret of SARS-CoV-2 variants of interest/concern and immune escape.Fuxing LouMaochen LiZehan PangLin JiangLin GuanLili TianJiaming HuJunfen FanHuahao FanFrontiers Media S.A.articleSARS-CoV-2 variantsimmune escapevaccineneutralizing antibodyvariants of interestvariants of concernImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 variants immune escape vaccine neutralizing antibody variants of interest variants of concern Immunologic diseases. Allergy RC581-607
spellingShingle	SARS-CoV-2 variants immune escape vaccine neutralizing antibody variants of interest variants of concern Immunologic diseases. Allergy RC581-607 Fuxing Lou Maochen Li Zehan Pang Lin Jiang Lin Guan Lili Tian Jiaming Hu Junfen Fan Huahao Fan Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape
description	The global pandemic of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), places a heavy burden on global public health. Four SARS-CoV-2 variants of concern including B.1.1.7, B.1.351, B.1.617.2, and P.1, and two variants of interest including C.37 and B.1.621 have been reported to have potential immune escape, and one or more mutations endow them with worrisome epidemiologic, immunologic, or pathogenic characteristics. This review introduces the latest research progress on SARS-CoV-2 variants of interest and concern, key mutation sites, and their effects on virus infectivity, mortality, and immune escape. Moreover, we compared the effects of various clinical SARS-CoV-2 vaccines and convalescent sera on epidemic variants, and evaluated the neutralizing capability of several antibodies on epidemic variants. In the end, SARS-CoV-2 evolution strategies in different transmission stages, the impact of different vaccination strategies on SARS-CoV-2 immune escape, antibody therapy strategies and COVID-19 epidemic control prospects are discussed. This review will provide a systematic and comprehensive understanding of the secret of SARS-CoV-2 variants of interest/concern and immune escape.
format	article
author	Fuxing Lou Maochen Li Zehan Pang Lin Jiang Lin Guan Lili Tian Jiaming Hu Junfen Fan Huahao Fan
author_facet	Fuxing Lou Maochen Li Zehan Pang Lin Jiang Lin Guan Lili Tian Jiaming Hu Junfen Fan Huahao Fan
author_sort	Fuxing Lou
title	Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape
title_short	Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape
title_full	Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape
title_fullStr	Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape
title_full_unstemmed	Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape
title_sort	understanding the secret of sars-cov-2 variants of concern/interest and immune escape
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5a4c978ca4124e15b649e837177f3176
work_keys_str_mv	AT fuxinglou understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT maochenli understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT zehanpang understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT linjiang understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT linguan understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT lilitian understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT jiaminghu understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT junfenfan understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape AT huahaofan understandingthesecretofsarscov2variantsofconcerninterestandimmuneescape
_version_	1718444228646797312

Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune Escape

Ejemplares similares