Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease

Graves’ disease is an autoimmune condition leading to the activation of and an increase in thyroid hormone secretion. Manifestations of hyperthyroidism in Graves’ disease can vary among people. In this case, we report a 24-year-old Thai man with a rare presentation of unilateral gynecomastia along w...

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Autores principales:	Titipatima Sakulterdkiat, Kessanee Romphothong, Waralee Chatchomchuan, Soontaree Nakasatien, Sirinate Krittiyawong, Yotsapon Thewjitcharoen, Thep Himathongkam
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/5a4ddafdc5524cd2b7e5d7be132b1ed8
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spelling	oai:doaj.org-article:5a4ddafdc5524cd2b7e5d7be132b1ed82021-11-10T11:58:17ZUnilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease10.1530/EDM-20-01402052-0573https://doaj.org/article/5a4ddafdc5524cd2b7e5d7be132b1ed82021-11-01T00:00:00Zhttps://edm.bioscientifica.com/view/journals/edm/2021/1/EDM20-0140.xmlhttps://doaj.org/toc/2052-0573Graves’ disease is an autoimmune condition leading to the activation of and an increase in thyroid hormone secretion. Manifestations of hyperthyroidism in Graves’ disease can vary among people. In this case, we report a 24-year-old Thai man with a rare presentation of unilateral gynecomastia along with symptoms of thyrotoxicosis. Physical examination revealed a 3 cm non-tender palpable glandular tissue beneath and around the left areola without nipple discharge and moderately diffuse thyroid enlargement with thyroid bruit. Thyroid function test showed a typical thyrotoxicosis state with elevated serum-free T4 and decreased serum TSH. His diagnosis of Graves’ disease was confirmed biochemically with a highly elevated anti-TSH receptor antibody. Early treatment with anti-thyroid medication was given first, followed by Radioiodine treatment (RAI) for definitive treatment due to high level of anti-TSH receptor antibody, enlarged thyroid and severe thyrotoxicosis presentation at a young age, which might not resolve by anti-thyroid medication alone. The patient responded well to treatment and achieved complete resolution of unilateral gynecomastia with clinically and biochemically euthyroid within 3 months after treatment. No recurrent gynecomastia was found during the 2-year follow-up.Titipatima SakulterdkiatKessanee RomphothongWaralee ChatchomchuanSoontaree NakasatienSirinate KrittiyawongYotsapon ThewjitcharoenThep HimathongkamBioscientificaarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Titipatima Sakulterdkiat Kessanee Romphothong Waralee Chatchomchuan Soontaree Nakasatien Sirinate Krittiyawong Yotsapon Thewjitcharoen Thep Himathongkam Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease
description	Graves’ disease is an autoimmune condition leading to the activation of and an increase in thyroid hormone secretion. Manifestations of hyperthyroidism in Graves’ disease can vary among people. In this case, we report a 24-year-old Thai man with a rare presentation of unilateral gynecomastia along with symptoms of thyrotoxicosis. Physical examination revealed a 3 cm non-tender palpable glandular tissue beneath and around the left areola without nipple discharge and moderately diffuse thyroid enlargement with thyroid bruit. Thyroid function test showed a typical thyrotoxicosis state with elevated serum-free T4 and decreased serum TSH. His diagnosis of Graves’ disease was confirmed biochemically with a highly elevated anti-TSH receptor antibody. Early treatment with anti-thyroid medication was given first, followed by Radioiodine treatment (RAI) for definitive treatment due to high level of anti-TSH receptor antibody, enlarged thyroid and severe thyrotoxicosis presentation at a young age, which might not resolve by anti-thyroid medication alone. The patient responded well to treatment and achieved complete resolution of unilateral gynecomastia with clinically and biochemically euthyroid within 3 months after treatment. No recurrent gynecomastia was found during the 2-year follow-up.
format	article
author	Titipatima Sakulterdkiat Kessanee Romphothong Waralee Chatchomchuan Soontaree Nakasatien Sirinate Krittiyawong Yotsapon Thewjitcharoen Thep Himathongkam
author_facet	Titipatima Sakulterdkiat Kessanee Romphothong Waralee Chatchomchuan Soontaree Nakasatien Sirinate Krittiyawong Yotsapon Thewjitcharoen Thep Himathongkam
author_sort	Titipatima Sakulterdkiat
title	Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease
title_short	Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease
title_full	Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease
title_fullStr	Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease
title_full_unstemmed	Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease
title_sort	unilateral gynecomastia as an initial presentation of hyperthyroid graves’ disease
publisher	Bioscientifica
publishDate	2021
url	https://doaj.org/article/5a4ddafdc5524cd2b7e5d7be132b1ed8
work_keys_str_mv	AT titipatimasakulterdkiat unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease AT kessaneeromphothong unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease AT waraleechatchomchuan unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease AT soontareenakasatien unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease AT sirinatekrittiyawong unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease AT yotsaponthewjitcharoen unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease AT thephimathongkam unilateralgynecomastiaasaninitialpresentationofhyperthyroidgravesdisease
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Unilateral gynecomastia as an initial presentation of hyperthyroid Graves’ disease

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