Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular resp...

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Autores principales:	Nicola Fenderico, Revina C. van Scherpenzeel, Michael Goldflam, Davide Proverbio, Ingrid Jordens, Tomica Kralj, Sarah Stryeck, Tarek Z. Bass, Guy Hermans, Christopher Ullman, Teodor Aastrup, Piet Gros, Madelon M. Maurice
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a4f5bbea0514b429431ef3636e2ef04
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spelling	oai:doaj.org-article:5a4f5bbea0514b429431ef3636e2ef042021-12-02T14:35:36ZAnti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells10.1038/s41467-018-08172-z2041-1723https://doaj.org/article/5a4f5bbea0514b429431ef3636e2ef042019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08172-zhttps://doaj.org/toc/2041-1723Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.Nicola FendericoRevina C. van ScherpenzeelMichael GoldflamDavide ProverbioIngrid JordensTomica KraljSarah StryeckTarek Z. BassGuy HermansChristopher UllmanTeodor AastrupPiet GrosMadelon M. MauriceNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicola Fenderico Revina C. van Scherpenzeel Michael Goldflam Davide Proverbio Ingrid Jordens Tomica Kralj Sarah Stryeck Tarek Z. Bass Guy Hermans Christopher Ullman Teodor Aastrup Piet Gros Madelon M. Maurice Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
description	Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.
format	article
author	Nicola Fenderico Revina C. van Scherpenzeel Michael Goldflam Davide Proverbio Ingrid Jordens Tomica Kralj Sarah Stryeck Tarek Z. Bass Guy Hermans Christopher Ullman Teodor Aastrup Piet Gros Madelon M. Maurice
author_facet	Nicola Fenderico Revina C. van Scherpenzeel Michael Goldflam Davide Proverbio Ingrid Jordens Tomica Kralj Sarah Stryeck Tarek Z. Bass Guy Hermans Christopher Ullman Teodor Aastrup Piet Gros Madelon M. Maurice
author_sort	Nicola Fenderico
title	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
title_short	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
title_full	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
title_fullStr	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
title_full_unstemmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
title_sort	anti-lrp5/6 vhhs promote differentiation of wnt-hypersensitive intestinal stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5a4f5bbea0514b429431ef3636e2ef04
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Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

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