Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p

Increasing evidence demonstrated long non-coding RNAs (lncRNAs) play important roles in the occurrence and development of oral squamous cell carcinoma (OSCC). This study aimed to explore the role and molecular mechanism of lncRNA HOXA-AS3 in the progression of OSCC. Here, we found that the expressio...

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Autores principales:	Yue Zhao, Rui Yao
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	oral squamous cell carcinoma lncrna hoxa-as3 mir-218-5p proliferation Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/5a4fcb0f602747d583f0bf29410f9a23
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spelling	oai:doaj.org-article:5a4fcb0f602747d583f0bf29410f9a232021-11-04T15:51:53ZLong non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p2165-59792165-598710.1080/21655979.2021.1978196https://doaj.org/article/5a4fcb0f602747d583f0bf29410f9a232021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1978196https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Increasing evidence demonstrated long non-coding RNAs (lncRNAs) play important roles in the occurrence and development of oral squamous cell carcinoma (OSCC). This study aimed to explore the role and molecular mechanism of lncRNA HOXA-AS3 in the progression of OSCC. Here, we found that the expression of lncRNA HOXA-AS3 was upregulated in OSCC tissues and cell lines compared with the para-cancerous tissues and normal human oral keratinocyte (NHOK), respectively. Inhibition of HOXA-AS3 significantly inhibited the proliferation and colony formation of OSCC cells. Further, the luciferase reporter assay showed that HOXA-AS3 was directly bound to miR-218-5p. Moreover, the expression of miR-218-5p was negatively regulated by HOXA-AS3, and miR-218-5p could inhibit the expression of collagen type I alpha1 (COL1A1) and lysophosphatidylcholine acyltransferase 1 (LPCAT1). In addition, silencing miR-218-5p reversed the inhibitory effect of HOXA-AS3 knockdown on the proliferative potential of OSCC cells. In summary, our study illustrated that HOXA-AS3 promoted cancer cell proliferation in OSCC, possibly by sponging miR-218-5p for the first time, which provides a new target or a potential diagnostic biomarker for OSCC.Yue ZhaoRui YaoTaylor & Francis Grouparticleoral squamous cell carcinomalncrnahoxa-as3mir-218-5pproliferationBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 8724-8737 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral squamous cell carcinoma lncrna hoxa-as3 mir-218-5p proliferation Biotechnology TP248.13-248.65
spellingShingle	oral squamous cell carcinoma lncrna hoxa-as3 mir-218-5p proliferation Biotechnology TP248.13-248.65 Yue Zhao Rui Yao Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
description	Increasing evidence demonstrated long non-coding RNAs (lncRNAs) play important roles in the occurrence and development of oral squamous cell carcinoma (OSCC). This study aimed to explore the role and molecular mechanism of lncRNA HOXA-AS3 in the progression of OSCC. Here, we found that the expression of lncRNA HOXA-AS3 was upregulated in OSCC tissues and cell lines compared with the para-cancerous tissues and normal human oral keratinocyte (NHOK), respectively. Inhibition of HOXA-AS3 significantly inhibited the proliferation and colony formation of OSCC cells. Further, the luciferase reporter assay showed that HOXA-AS3 was directly bound to miR-218-5p. Moreover, the expression of miR-218-5p was negatively regulated by HOXA-AS3, and miR-218-5p could inhibit the expression of collagen type I alpha1 (COL1A1) and lysophosphatidylcholine acyltransferase 1 (LPCAT1). In addition, silencing miR-218-5p reversed the inhibitory effect of HOXA-AS3 knockdown on the proliferative potential of OSCC cells. In summary, our study illustrated that HOXA-AS3 promoted cancer cell proliferation in OSCC, possibly by sponging miR-218-5p for the first time, which provides a new target or a potential diagnostic biomarker for OSCC.
format	article
author	Yue Zhao Rui Yao
author_facet	Yue Zhao Rui Yao
author_sort	Yue Zhao
title	Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
title_short	Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
title_full	Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
title_fullStr	Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
title_full_unstemmed	Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
title_sort	long non-coding rna hoxa-as3 promotes cell proliferation of oral squamous cell carcinoma through sponging microrna mir-218-5p
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5a4fcb0f602747d583f0bf29410f9a23
work_keys_str_mv	AT yuezhao longnoncodingrnahoxaas3promotescellproliferationoforalsquamouscellcarcinomathroughspongingmicrornamir2185p AT ruiyao longnoncodingrnahoxaas3promotescellproliferationoforalsquamouscellcarcinomathroughspongingmicrornamir2185p
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Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p

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