Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage

Abstract A dysregulation of cytokine networks has been suggested to be involved in the pathogenesis of unexplained pregnancy loss. Gut microbiota affects host immune response and induces an imbalance in cytokine levels. However, how gut microbial dysbiosis disturbs cellular immune function in miscar...

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Autores principales:	Yongjie Liu, Hainan Chen, Liping Feng, Jun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/5a508951c86e429a83ee8b5d03e03074
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spelling	oai:doaj.org-article:5a508951c86e429a83ee8b5d03e030742021-12-02T16:31:03ZInteractions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage10.1038/s41522-021-00199-32055-5008https://doaj.org/article/5a508951c86e429a83ee8b5d03e030742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00199-3https://doaj.org/toc/2055-5008Abstract A dysregulation of cytokine networks has been suggested to be involved in the pathogenesis of unexplained pregnancy loss. Gut microbiota affects host immune response and induces an imbalance in cytokine levels. However, how gut microbial dysbiosis disturbs cellular immune function in miscarriage remains inconclusive. Here we report that IL-2, IL-17A, IL-17F, TNF-α, and IFN-γ are significantly increased in serum of miscarriage patients. Fecal microbiome analyses indicate that microbial diversity and the relative abundances of Prevotella_1, Prevotellaceae_UCG_003 and Selenomonas_1 are significantly reduced in the cases. Correlation analyses indicate that some microbe-associated metabolites are positively associated with changes in levels of Th1/Th17 cytokines in the miscarriage group. Moreover, we identify that imidazolepropionic acid and 1,4-methylimidazoleacetic acid are associated with subsequent recurrent miscarriage. Our study highlights the network among gut microbiota, fecal metabolites and Th1/Th17-mediated immune response in miscarriage patients and explores the potential predictive values of two fecal metabolites for recurrent miscarriages.Yongjie LiuHainan ChenLiping FengJun ZhangNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Yongjie Liu Hainan Chen Liping Feng Jun Zhang Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
description	Abstract A dysregulation of cytokine networks has been suggested to be involved in the pathogenesis of unexplained pregnancy loss. Gut microbiota affects host immune response and induces an imbalance in cytokine levels. However, how gut microbial dysbiosis disturbs cellular immune function in miscarriage remains inconclusive. Here we report that IL-2, IL-17A, IL-17F, TNF-α, and IFN-γ are significantly increased in serum of miscarriage patients. Fecal microbiome analyses indicate that microbial diversity and the relative abundances of Prevotella_1, Prevotellaceae_UCG_003 and Selenomonas_1 are significantly reduced in the cases. Correlation analyses indicate that some microbe-associated metabolites are positively associated with changes in levels of Th1/Th17 cytokines in the miscarriage group. Moreover, we identify that imidazolepropionic acid and 1,4-methylimidazoleacetic acid are associated with subsequent recurrent miscarriage. Our study highlights the network among gut microbiota, fecal metabolites and Th1/Th17-mediated immune response in miscarriage patients and explores the potential predictive values of two fecal metabolites for recurrent miscarriages.
format	article
author	Yongjie Liu Hainan Chen Liping Feng Jun Zhang
author_facet	Yongjie Liu Hainan Chen Liping Feng Jun Zhang
author_sort	Yongjie Liu
title	Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
title_short	Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
title_full	Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
title_fullStr	Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
title_full_unstemmed	Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
title_sort	interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a508951c86e429a83ee8b5d03e03074
work_keys_str_mv	AT yongjieliu interactionsbetweengutmicrobiotaandmetabolitesmodulatecytokinenetworkimbalancesinwomenwithunexplainedmiscarriage AT hainanchen interactionsbetweengutmicrobiotaandmetabolitesmodulatecytokinenetworkimbalancesinwomenwithunexplainedmiscarriage AT lipingfeng interactionsbetweengutmicrobiotaandmetabolitesmodulatecytokinenetworkimbalancesinwomenwithunexplainedmiscarriage AT junzhang interactionsbetweengutmicrobiotaandmetabolitesmodulatecytokinenetworkimbalancesinwomenwithunexplainedmiscarriage
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Interactions between gut microbiota and metabolites modulate cytokine network imbalances in women with unexplained miscarriage

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