A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis
In patients with cystic fibrosis, IL-9 signalling is increased. The authors describe an inflammatory loop in which IL-9 produced by Th9 cells drives mast cells to produce IL-2, resulting in ILC2 cell activation, and show inhibition of this loop with blocking antibodies to IL-9 in a mouse model of pu...
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Nature Portfolio
2017
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oai:doaj.org-article:5a5105499b234761b49ef00baa79cfac2021-12-02T14:42:02ZA mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis10.1038/ncomms140172041-1723https://doaj.org/article/5a5105499b234761b49ef00baa79cfac2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14017https://doaj.org/toc/2041-1723In patients with cystic fibrosis, IL-9 signalling is increased. The authors describe an inflammatory loop in which IL-9 produced by Th9 cells drives mast cells to produce IL-2, resulting in ILC2 cell activation, and show inhibition of this loop with blocking antibodies to IL-9 in a mouse model of pulmonary infection.Silvia MorettiGiorgia RengaVasilis OikonomouClaudia GalosiMarilena ParianoRossana G. IannittiMonica BorghiMatteo PuccettiMarco De ZuaniCarlo E. PucilloGiuseppe PaolicelliTeresa ZelanteJean-Christophe RenauldOxana BereshchenkoPaolo SportolettiVincenzina LucidiMaria Chiara RussoCarla ColomboErsilia FiscarelliCornelia Lass-FlörlFabio MajoGabriella RicciottiHelmut EllemunterLuigi RatclifVincenzo Nicola TalesaValerio NapolioniLuigina RomaniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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DOAJ |
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EN |
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Science Q Silvia Moretti Giorgia Renga Vasilis Oikonomou Claudia Galosi Marilena Pariano Rossana G. Iannitti Monica Borghi Matteo Puccetti Marco De Zuani Carlo E. Pucillo Giuseppe Paolicelli Teresa Zelante Jean-Christophe Renauld Oxana Bereshchenko Paolo Sportoletti Vincenzina Lucidi Maria Chiara Russo Carla Colombo Ersilia Fiscarelli Cornelia Lass-Flörl Fabio Majo Gabriella Ricciotti Helmut Ellemunter Luigi Ratclif Vincenzo Nicola Talesa Valerio Napolioni Luigina Romani A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis |
| description |
In patients with cystic fibrosis, IL-9 signalling is increased. The authors describe an inflammatory loop in which IL-9 produced by Th9 cells drives mast cells to produce IL-2, resulting in ILC2 cell activation, and show inhibition of this loop with blocking antibodies to IL-9 in a mouse model of pulmonary infection. |
| format |
article |
| author |
Silvia Moretti Giorgia Renga Vasilis Oikonomou Claudia Galosi Marilena Pariano Rossana G. Iannitti Monica Borghi Matteo Puccetti Marco De Zuani Carlo E. Pucillo Giuseppe Paolicelli Teresa Zelante Jean-Christophe Renauld Oxana Bereshchenko Paolo Sportoletti Vincenzina Lucidi Maria Chiara Russo Carla Colombo Ersilia Fiscarelli Cornelia Lass-Flörl Fabio Majo Gabriella Ricciotti Helmut Ellemunter Luigi Ratclif Vincenzo Nicola Talesa Valerio Napolioni Luigina Romani |
| author_facet |
Silvia Moretti Giorgia Renga Vasilis Oikonomou Claudia Galosi Marilena Pariano Rossana G. Iannitti Monica Borghi Matteo Puccetti Marco De Zuani Carlo E. Pucillo Giuseppe Paolicelli Teresa Zelante Jean-Christophe Renauld Oxana Bereshchenko Paolo Sportoletti Vincenzina Lucidi Maria Chiara Russo Carla Colombo Ersilia Fiscarelli Cornelia Lass-Flörl Fabio Majo Gabriella Ricciotti Helmut Ellemunter Luigi Ratclif Vincenzo Nicola Talesa Valerio Napolioni Luigina Romani |
| author_sort |
Silvia Moretti |
| title |
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis |
| title_short |
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis |
| title_full |
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis |
| title_fullStr |
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis |
| title_full_unstemmed |
A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis |
| title_sort |
mast cell-ilc2-th9 pathway promotes lung inflammation in cystic fibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/5a5105499b234761b49ef00baa79cfac |
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