Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study

Abstract Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtai...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yue Liu, Jieqiong Wang, Jishui Zhang, Hongwei Wen, Yue Zhang, Huiying Kang, Xu Wang, Wenfeng Li, Huiguang He, Yun Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a52833a014946c1b255e41af2395545
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a52833a014946c1b255e41af2395545
record_format	dspace
spelling	oai:doaj.org-article:5a52833a014946c1b255e41af23955452021-12-02T16:06:46ZAltered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study10.1038/s41598-017-04148-z2045-2322https://doaj.org/article/5a52833a014946c1b255e41af23955452017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04148-zhttps://doaj.org/toc/2045-2322Abstract Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naïve and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.Yue LiuJieqiong WangJishui ZhangHongwei WenYue ZhangHuiying KangXu WangWenfeng LiHuiguang HeYun PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yue Liu Jieqiong Wang Jishui Zhang Hongwei Wen Yue Zhang Huiying Kang Xu Wang Wenfeng Li Huiguang He Yun Peng Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
description	Abstract Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naïve and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.
format	article
author	Yue Liu Jieqiong Wang Jishui Zhang Hongwei Wen Yue Zhang Huiying Kang Xu Wang Wenfeng Li Huiguang He Yun Peng
author_facet	Yue Liu Jieqiong Wang Jishui Zhang Hongwei Wen Yue Zhang Huiying Kang Xu Wang Wenfeng Li Huiguang He Yun Peng
author_sort	Yue Liu
title	Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
title_short	Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
title_full	Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
title_fullStr	Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
title_full_unstemmed	Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
title_sort	altered spontaneous brain activity in children with early tourette syndrome: a resting-state fmri study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5a52833a014946c1b255e41af2395545
work_keys_str_mv	AT yueliu alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT jieqiongwang alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT jishuizhang alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT hongweiwen alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT yuezhang alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT huiyingkang alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT xuwang alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT wenfengli alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT huiguanghe alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy AT yunpeng alteredspontaneousbrainactivityinchildrenwithearlytourettesyndromearestingstatefmristudy
_version_	1718384842023895040

Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study

Ejemplares similares