A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy

Hairong Wang, Yawen Zhang, Xiangle Zeng, Wenjun Pei, Ranran Fan, Yushuai Wang, Xiu Wang, Jianchun Li School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaCorrespondence: Jianchun LiSchool of Pharmacy, Bengbu Medical College, Bengbu, 233030, People&rsquo...

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Autores principales:	Wang H, Zhang Y, Zeng X, Pei W, Fan R, Wang Y, Wang X, Li J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	ha targeting inhibiting metastasis polymer micelle Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5a52b36423bc47a5b738f9edff393d6c
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spelling	oai:doaj.org-article:5a52b36423bc47a5b738f9edff393d6c2021-12-02T16:05:34ZA Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy1178-2013https://doaj.org/article/5a52b36423bc47a5b738f9edff393d6c2021-03-01T00:00:00Zhttps://www.dovepress.com/a-combined-self-assembled-drug-delivery-for-effective-anti-breast-canc-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hairong Wang, Yawen Zhang, Xiangle Zeng, Wenjun Pei, Ranran Fan, Yushuai Wang, Xiu Wang, Jianchun Li School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaCorrespondence: Jianchun LiSchool of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaTel +86 552-3175066Email Lijc66577@sohu.comAim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies.Methods: Hyaluronic acid (HA) and DAS are bonded by a pH-sensitive ester bond to form an HA-DAS polymer. Then, ROZ was added as the core, D-A-tocopherol polydiethylene glycol isosuccinate (TPGS) and HA-DAS were used as carriers to form HA-DAS and TPGS mixed micelle system loaded with ROZ (THDR-NPs). The size and structure of THDR-NPs were characterized, the drug release, stability and biosafety of THDR-NPs were studied. In vitro, the cytotoxicity, targeting effect and tumor metastasis inhibition of THDR-NPs were evaluated in human breast cancer cell lines. In addition, the selective potency of designed THDR-NPs in depleting was further verified in vivo in the tumor-bearing nude mice model.Results: The designed THDR-NPs have a particle size of less than 100 nm, good stability, biological safety and sustained release, and showed strong therapeutic effects on breast cancer models in vitro and in vivo. Moreover, it has been proved that THDR-NPs have the ability to inhibit tumor metastasis.Conclusion: DAS and ROZ were designed into micelles, the efficacy of THDR-NPs was higher than that of free drugs. These results indicate that nanoparticles have a good application prospect in the treatment of tumor metastasis.Keywords: HA targeting, inhibiting metastasis, polymer, micelleWang HZhang YZeng XPei WFan RWang YWang XLi JDove Medical Pressarticleha targetinginhibiting metastasispolymermicelleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2373-2388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ha targeting inhibiting metastasis polymer micelle Medicine (General) R5-920
spellingShingle	ha targeting inhibiting metastasis polymer micelle Medicine (General) R5-920 Wang H Zhang Y Zeng X Pei W Fan R Wang Y Wang X Li J A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
description	Hairong Wang, Yawen Zhang, Xiangle Zeng, Wenjun Pei, Ranran Fan, Yushuai Wang, Xiu Wang, Jianchun Li School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaCorrespondence: Jianchun LiSchool of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaTel +86 552-3175066Email Lijc66577@sohu.comAim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies.Methods: Hyaluronic acid (HA) and DAS are bonded by a pH-sensitive ester bond to form an HA-DAS polymer. Then, ROZ was added as the core, D-A-tocopherol polydiethylene glycol isosuccinate (TPGS) and HA-DAS were used as carriers to form HA-DAS and TPGS mixed micelle system loaded with ROZ (THDR-NPs). The size and structure of THDR-NPs were characterized, the drug release, stability and biosafety of THDR-NPs were studied. In vitro, the cytotoxicity, targeting effect and tumor metastasis inhibition of THDR-NPs were evaluated in human breast cancer cell lines. In addition, the selective potency of designed THDR-NPs in depleting was further verified in vivo in the tumor-bearing nude mice model.Results: The designed THDR-NPs have a particle size of less than 100 nm, good stability, biological safety and sustained release, and showed strong therapeutic effects on breast cancer models in vitro and in vivo. Moreover, it has been proved that THDR-NPs have the ability to inhibit tumor metastasis.Conclusion: DAS and ROZ were designed into micelles, the efficacy of THDR-NPs was higher than that of free drugs. These results indicate that nanoparticles have a good application prospect in the treatment of tumor metastasis.Keywords: HA targeting, inhibiting metastasis, polymer, micelle
format	article
author	Wang H Zhang Y Zeng X Pei W Fan R Wang Y Wang X Li J
author_facet	Wang H Zhang Y Zeng X Pei W Fan R Wang Y Wang X Li J
author_sort	Wang H
title	A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
title_short	A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
title_full	A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
title_fullStr	A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
title_full_unstemmed	A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
title_sort	combined self-assembled drug delivery for effective anti-breast cancer therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5a52b36423bc47a5b738f9edff393d6c
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A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy

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