Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

Joyce S Ramos,1,2 Lance C Dalleck,2,3 Rebecca C Stennett,1 Gregore I Mielke,1 Shelley E Keating,1 Lydia Murray,4 Sumaira Z Hasnain,4,5 Robert G Fassett,1 Michael McGuckin,4,6 Ilaria Croci,1,7 Jeff S Coombes1 1Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and...

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Autores principales:	Ramos JS, Dalleck LC, Stennett RC, Mielke GI, Keating SE, Murray L, Hasnain SZ, Fassett RG, McGuckin M, Croci I, Coombes JS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	high-intensity interval training il-22 inflammation cardiovascular disease metabolic syndrome cytokine Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5a594af06f344d05a71fdb68312680ad
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id	oai:doaj.org-article:5a594af06f344d05a71fdb68312680ad
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	high-intensity interval training il-22 inflammation cardiovascular disease metabolic syndrome cytokine Specialties of internal medicine RC581-951
spellingShingle	high-intensity interval training il-22 inflammation cardiovascular disease metabolic syndrome cytokine Specialties of internal medicine RC581-951 Ramos JS Dalleck LC Stennett RC Mielke GI Keating SE Murray L Hasnain SZ Fassett RG McGuckin M Croci I Coombes JS Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial
description	Joyce S Ramos,1,2 Lance C Dalleck,2,3 Rebecca C Stennett,1 Gregore I Mielke,1 Shelley E Keating,1 Lydia Murray,4 Sumaira Z Hasnain,4,5 Robert G Fassett,1 Michael McGuckin,4,6 Ilaria Croci,1,7 Jeff S Coombes1 1Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia; 2Caring Futures Institute and SHAPE Research Centre, Exercise Science and Clinical Exercise Physiology, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia; 3Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, Colorado, USA; 4Immunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia; 5Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia; 6Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia; 7K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Sor Trondelag, NorwayCorrespondence: Joyce S Ramos Email joyce.ramos@flinders.edu.auIntroduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60– 70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85– 95% HR peak, interspersed with 3min of active recovery at 50– 70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85– 95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.Results: The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were − 17% (− 43.0% to 31.3%), +16.5% (− 18.9% to 154.9%), and +15.9% (− 28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η2=0.14].Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.Keywords: high-intensity interval training, IL-22, inflammation, cardiovascular disease, metabolic syndrome, cytokine
format	article
author	Ramos JS Dalleck LC Stennett RC Mielke GI Keating SE Murray L Hasnain SZ Fassett RG McGuckin M Croci I Coombes JS
author_facet	Ramos JS Dalleck LC Stennett RC Mielke GI Keating SE Murray L Hasnain SZ Fassett RG McGuckin M Croci I Coombes JS
author_sort	Ramos JS
title	Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial
title_short	Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial
title_full	Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial
title_fullStr	Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial
title_full_unstemmed	Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial
title_sort	effect of different volumes of interval training and continuous exercise on interleukin-22 in adults with metabolic syndrome: a randomized trial
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5a594af06f344d05a71fdb68312680ad
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spelling	oai:doaj.org-article:5a594af06f344d05a71fdb68312680ad2021-12-02T10:41:06ZEffect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial1178-7007https://doaj.org/article/5a594af06f344d05a71fdb68312680ad2020-07-01T00:00:00Zhttps://www.dovepress.com/effect-of-different-volumes-of-interval-training-and-continuous-exerci-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Joyce S Ramos,1,2 Lance C Dalleck,2,3 Rebecca C Stennett,1 Gregore I Mielke,1 Shelley E Keating,1 Lydia Murray,4 Sumaira Z Hasnain,4,5 Robert G Fassett,1 Michael McGuckin,4,6 Ilaria Croci,1,7 Jeff S Coombes1 1Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia; 2Caring Futures Institute and SHAPE Research Centre, Exercise Science and Clinical Exercise Physiology, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia; 3Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, Colorado, USA; 4Immunopathology Group, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia; 5Australian Infectious Disease Research Centre, University of Queensland, Brisbane, Queensland, Australia; 6Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia; 7K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Sor Trondelag, NorwayCorrespondence: Joyce S Ramos Email joyce.ramos@flinders.edu.auIntroduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60– 70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85– 95% HR peak, interspersed with 3min of active recovery at 50– 70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85– 95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.Results: The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were − 17% (− 43.0% to 31.3%), +16.5% (− 18.9% to 154.9%), and +15.9% (− 28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η2=0.14].Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.Keywords: high-intensity interval training, IL-22, inflammation, cardiovascular disease, metabolic syndrome, cytokineRamos JSDalleck LCStennett RCMielke GIKeating SEMurray LHasnain SZFassett RGMcGuckin MCroci ICoombes JSDove Medical Pressarticlehigh-intensity interval trainingil-22inflammationcardiovascular diseasemetabolic syndromecytokineSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2443-2453 (2020)

Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

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