Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects...

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Autores principales:	Yifei Zhong, Kyung Lee, Yueyi Deng, Yueming Ma, Yiping Chen, Xueling Li, Chengguo Wei, Shumin Yang, Tianming Wang, Nicholas J. Wong, Alecia N. Muwonge, Evren U. Azeloglu, Weijia Zhang, Bhaskar Das, John Cijiang He, Ruijie Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a5b2bbb2f2147bf8cd9959dcec76d0d
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spelling	oai:doaj.org-article:5a5b2bbb2f2147bf8cd9959dcec76d0d2021-12-02T15:35:12ZArctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes10.1038/s41467-019-12433-w2041-1723https://doaj.org/article/5a5b2bbb2f2147bf8cd9959dcec76d0d2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12433-whttps://doaj.org/toc/2041-1723Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects of ATG in mouse models of DKD.Yifei ZhongKyung LeeYueyi DengYueming MaYiping ChenXueling LiChengguo WeiShumin YangTianming WangNicholas J. WongAlecia N. MuwongeEvren U. AzelogluWeijia ZhangBhaskar DasJohn Cijiang HeRuijie LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifei Zhong Kyung Lee Yueyi Deng Yueming Ma Yiping Chen Xueling Li Chengguo Wei Shumin Yang Tianming Wang Nicholas J. Wong Alecia N. Muwonge Evren U. Azeloglu Weijia Zhang Bhaskar Das John Cijiang He Ruijie Liu Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
description	Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects of ATG in mouse models of DKD.
format	article
author	Yifei Zhong Kyung Lee Yueyi Deng Yueming Ma Yiping Chen Xueling Li Chengguo Wei Shumin Yang Tianming Wang Nicholas J. Wong Alecia N. Muwonge Evren U. Azeloglu Weijia Zhang Bhaskar Das John Cijiang He Ruijie Liu
author_facet	Yifei Zhong Kyung Lee Yueyi Deng Yueming Ma Yiping Chen Xueling Li Chengguo Wei Shumin Yang Tianming Wang Nicholas J. Wong Alecia N. Muwonge Evren U. Azeloglu Weijia Zhang Bhaskar Das John Cijiang He Ruijie Liu
author_sort	Yifei Zhong
title	Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
title_short	Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
title_full	Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
title_fullStr	Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
title_full_unstemmed	Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
title_sort	arctigenin attenuates diabetic kidney disease through the activation of pp2a in podocytes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5a5b2bbb2f2147bf8cd9959dcec76d0d
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Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes

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