A common minimal motif for the ligands of HLA-B*27 class I molecules.

CD8(+) T cells identify and kill infected cells through the specific recognition of short viral antigens bound to human major histocompatibility complex (HLA) class I molecules. The colossal number of polymorphisms in HLA molecules makes it essential to characterize the antigen-presenting properties...

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Autores principales:	Alejandro Barriga, Elena Lorente, Carolina Johnstone, Carmen Mir, Margarita del Val, Daniel López
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a5b8c1e23584f618bf183aba679ee3c
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spelling	oai:doaj.org-article:5a5b8c1e23584f618bf183aba679ee3c2021-11-25T05:58:30ZA common minimal motif for the ligands of HLA-B27 class I molecules.1932-620310.1371/journal.pone.0106772https://doaj.org/article/5a5b8c1e23584f618bf183aba679ee3c2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0106772https://doaj.org/toc/1932-6203CD8(+) T cells identify and kill infected cells through the specific recognition of short viral antigens bound to human major histocompatibility complex (HLA) class I molecules. The colossal number of polymorphisms in HLA molecules makes it essential to characterize the antigen-presenting properties common to large HLA families or supertypes. In this context, the HLA-B27 family comprising at least 100 different alleles, some of them widely distributed in the human population, is involved in the cellular immune response against pathogens and also associated to autoimmune spondyloarthritis being thus a relevant target of study. To this end, HLA binding assays performed using nine HLA-B2705-restricted ligands endogenously processed and presented in virus-infected cells revealed a common minimal peptide motif for efficient binding to the HLA-B27 family. The motif was independently confirmed using four unrelated peptides. This experimental approach, which could be easily transferred to other HLA class I families and supertypes, has implications for the validation of new bioinformatics tools in the functional clustering of HLA molecules, for the identification of antiviral cytotoxic T lymphocyte responses, and for future vaccine development.Alejandro BarrigaElena LorenteCarolina JohnstoneCarmen MirMargarita del ValDaniel LópezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e106772 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alejandro Barriga Elena Lorente Carolina Johnstone Carmen Mir Margarita del Val Daniel López A common minimal motif for the ligands of HLA-B*27 class I molecules.
description	CD8(+) T cells identify and kill infected cells through the specific recognition of short viral antigens bound to human major histocompatibility complex (HLA) class I molecules. The colossal number of polymorphisms in HLA molecules makes it essential to characterize the antigen-presenting properties common to large HLA families or supertypes. In this context, the HLA-B27 family comprising at least 100 different alleles, some of them widely distributed in the human population, is involved in the cellular immune response against pathogens and also associated to autoimmune spondyloarthritis being thus a relevant target of study. To this end, HLA binding assays performed using nine HLA-B2705-restricted ligands endogenously processed and presented in virus-infected cells revealed a common minimal peptide motif for efficient binding to the HLA-B*27 family. The motif was independently confirmed using four unrelated peptides. This experimental approach, which could be easily transferred to other HLA class I families and supertypes, has implications for the validation of new bioinformatics tools in the functional clustering of HLA molecules, for the identification of antiviral cytotoxic T lymphocyte responses, and for future vaccine development.
format	article
author	Alejandro Barriga Elena Lorente Carolina Johnstone Carmen Mir Margarita del Val Daniel López
author_facet	Alejandro Barriga Elena Lorente Carolina Johnstone Carmen Mir Margarita del Val Daniel López
author_sort	Alejandro Barriga
title	A common minimal motif for the ligands of HLA-B*27 class I molecules.
title_short	A common minimal motif for the ligands of HLA-B*27 class I molecules.
title_full	A common minimal motif for the ligands of HLA-B*27 class I molecules.
title_fullStr	A common minimal motif for the ligands of HLA-B*27 class I molecules.
title_full_unstemmed	A common minimal motif for the ligands of HLA-B*27 class I molecules.
title_sort	common minimal motif for the ligands of hla-b*27 class i molecules.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5a5b8c1e23584f618bf183aba679ee3c
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A common minimal motif for the ligands of HLA-B*27 class I molecules.

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