Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.

<h4>Objective</h4>To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria.<h4>Materials and methods</h4>1002 coronary artery disease patients from the CO...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juan F Alcala-Diaz, Javier Delgado-Lista, Pablo Perez-Martinez, Antonio Garcia-Rios, Carmen Marin, Gracia M Quintana-Navarro, Purificacion Gomez-Luna, Antonio Camargo, Yolanda Almaden, Javier Caballero, Francisco J Tinahones, Jose M Ordovas, Francisco Perez-Jimenez, Jose Lopez-Miranda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a5f725f30bd422ebc0edf2326b893dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a5f725f30bd422ebc0edf2326b893dd
record_format	dspace
spelling	oai:doaj.org-article:5a5f725f30bd422ebc0edf2326b893dd2021-11-18T08:20:32ZHypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.1932-620310.1371/journal.pone.0096297https://doaj.org/article/5a5f725f30bd422ebc0edf2326b893dd2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24802225/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria.<h4>Materials and methods</h4>1002 coronary artery disease patients from the CORDIOPREV study were submitted to an oral fat load test meal with 0.7 g fat/kg body weight (12% saturated fatty acids, 10% polyunsaturated fatty acids, 43% monounsaturated fatty acids), 10% protein and 25% carbohydrates. Serial blood test analyzing lipid fractions were drawn at 0, 1, 2, 3 and 4 hours during the postprandial state. Total and incremental area under the curves of the different postprandial parameters were calculated following the trapezoid rule to assess the magnitude of change during the postprandial state.<h4>Results</h4>Postprandial lipemia response was directly related to the presence of metabolic syndrome. We found a positive association between the number of metabolic syndrome criteria and the response of postprandial plasma triglycerides (p<0.001), area under the curve of triglycerides (p<0.001) and incremental area under the curve of triglycerides (p<0.001). However, the influence of them on postprandial triglycerides remained statistically significant only in those patients without basal hypertriglyceridemia. Interestingly, in stepwise multiple linear regression analysis with the AUC of triglycerides as the dependent variable, only fasting triglycerides, fasting glucose and waist circumference appeared as significant independent (P<0.05) contributors. The multiple lineal regression (R) was 0.77, and fasting triglycerides showed the greatest effect on AUC of triglycerides with a standardized coefficient of 0.75.<h4>Conclusions</h4>Fasting triglycerides are the major contributors to the postprandial triglycerides levels. MetS influences the postprandial response of lipids in patients with coronary heart disease, particularly in non-hypertriglyceridemic patients.Juan F Alcala-DiazJavier Delgado-ListaPablo Perez-MartinezAntonio Garcia-RiosCarmen MarinGracia M Quintana-NavarroPurificacion Gomez-LunaAntonio CamargoYolanda AlmadenJavier CaballeroFrancisco J TinahonesJose M OrdovasFrancisco Perez-JimenezFrancisco Perez-JimenezJose Lopez-MirandaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96297 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juan F Alcala-Diaz Javier Delgado-Lista Pablo Perez-Martinez Antonio Garcia-Rios Carmen Marin Gracia M Quintana-Navarro Purificacion Gomez-Luna Antonio Camargo Yolanda Almaden Javier Caballero Francisco J Tinahones Jose M Ordovas Francisco Perez-Jimenez Francisco Perez-Jimenez Jose Lopez-Miranda Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.
description	<h4>Objective</h4>To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria.<h4>Materials and methods</h4>1002 coronary artery disease patients from the CORDIOPREV study were submitted to an oral fat load test meal with 0.7 g fat/kg body weight (12% saturated fatty acids, 10% polyunsaturated fatty acids, 43% monounsaturated fatty acids), 10% protein and 25% carbohydrates. Serial blood test analyzing lipid fractions were drawn at 0, 1, 2, 3 and 4 hours during the postprandial state. Total and incremental area under the curves of the different postprandial parameters were calculated following the trapezoid rule to assess the magnitude of change during the postprandial state.<h4>Results</h4>Postprandial lipemia response was directly related to the presence of metabolic syndrome. We found a positive association between the number of metabolic syndrome criteria and the response of postprandial plasma triglycerides (p<0.001), area under the curve of triglycerides (p<0.001) and incremental area under the curve of triglycerides (p<0.001). However, the influence of them on postprandial triglycerides remained statistically significant only in those patients without basal hypertriglyceridemia. Interestingly, in stepwise multiple linear regression analysis with the AUC of triglycerides as the dependent variable, only fasting triglycerides, fasting glucose and waist circumference appeared as significant independent (P<0.05) contributors. The multiple lineal regression (R) was 0.77, and fasting triglycerides showed the greatest effect on AUC of triglycerides with a standardized coefficient of 0.75.<h4>Conclusions</h4>Fasting triglycerides are the major contributors to the postprandial triglycerides levels. MetS influences the postprandial response of lipids in patients with coronary heart disease, particularly in non-hypertriglyceridemic patients.
format	article
author	Juan F Alcala-Diaz Javier Delgado-Lista Pablo Perez-Martinez Antonio Garcia-Rios Carmen Marin Gracia M Quintana-Navarro Purificacion Gomez-Luna Antonio Camargo Yolanda Almaden Javier Caballero Francisco J Tinahones Jose M Ordovas Francisco Perez-Jimenez Francisco Perez-Jimenez Jose Lopez-Miranda
author_facet	Juan F Alcala-Diaz Javier Delgado-Lista Pablo Perez-Martinez Antonio Garcia-Rios Carmen Marin Gracia M Quintana-Navarro Purificacion Gomez-Luna Antonio Camargo Yolanda Almaden Javier Caballero Francisco J Tinahones Jose M Ordovas Francisco Perez-Jimenez Francisco Perez-Jimenez Jose Lopez-Miranda
author_sort	Juan F Alcala-Diaz
title	Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.
title_short	Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.
title_full	Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.
title_fullStr	Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.
title_full_unstemmed	Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.
title_sort	hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the cordioprev study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5a5f725f30bd422ebc0edf2326b893dd
work_keys_str_mv	AT juanfalcaladiaz hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT javierdelgadolista hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT pabloperezmartinez hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT antoniogarciarios hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT carmenmarin hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT graciamquintananavarro hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT purificaciongomezluna hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT antoniocamargo hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT yolandaalmaden hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT javiercaballero hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT franciscojtinahones hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT josemordovas hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT franciscoperezjimenez hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT franciscoperezjimenez hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy AT joselopezmiranda hypertriglyceridemiainfluencesthedegreeofpostprandiallipemicresponseinpatientswithmetabolicsyndromeandcoronaryarterydiseasefromthecordioprevstudy
_version_	1718421862374965248

Hypertriglyceridemia influences the degree of postprandial lipemic response in patients with metabolic syndrome and coronary artery disease: from the CORDIOPREV study.

Ejemplares similares