Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocyt...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jérôme Carayol, Christian Chabert, Alessandro Di Cara, Claudia Armenise, Gregory Lefebvre, Dominique Langin, Nathalie Viguerie, Sylviane Metairon, Wim H. M. Saris, Arne Astrup, Patrick Descombes, Armand Valsesia, Jörg Hager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a5fba936b994740abf88acab0a29fef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a5fba936b994740abf88acab0a29fef
record_format	dspace
spelling	oai:doaj.org-article:5a5fba936b994740abf88acab0a29fef2021-12-02T15:38:56ZProtein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator10.1038/s41467-017-02182-z2041-1723https://doaj.org/article/5a5fba936b994740abf88acab0a29fef2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02182-zhttps://doaj.org/toc/2041-1723Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.Jérôme CarayolChristian ChabertAlessandro Di CaraClaudia ArmeniseGregory LefebvreDominique LanginNathalie ViguerieSylviane MetaironWim H. M. SarisArne AstrupPatrick DescombesArmand ValsesiaJörg HagerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jérôme Carayol Christian Chabert Alessandro Di Cara Claudia Armenise Gregory Lefebvre Dominique Langin Nathalie Viguerie Sylviane Metairon Wim H. M. Saris Arne Astrup Patrick Descombes Armand Valsesia Jörg Hager Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
description	Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.
format	article
author	Jérôme Carayol Christian Chabert Alessandro Di Cara Claudia Armenise Gregory Lefebvre Dominique Langin Nathalie Viguerie Sylviane Metairon Wim H. M. Saris Arne Astrup Patrick Descombes Armand Valsesia Jörg Hager
author_facet	Jérôme Carayol Christian Chabert Alessandro Di Cara Claudia Armenise Gregory Lefebvre Dominique Langin Nathalie Viguerie Sylviane Metairon Wim H. M. Saris Arne Astrup Patrick Descombes Armand Valsesia Jörg Hager
author_sort	Jérôme Carayol
title	Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_short	Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_full	Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_fullStr	Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_full_unstemmed	Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_sort	protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5a5fba936b994740abf88acab0a29fef
work_keys_str_mv	AT jeromecarayol proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT christianchabert proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT alessandrodicara proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT claudiaarmenise proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT gregorylefebvre proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT dominiquelangin proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT nathalieviguerie proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT sylvianemetairon proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT wimhmsaris proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT arneastrup proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT patrickdescombes proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT armandvalsesia proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator AT jorghager proteinquantitativetraitlocusstudyinobesityduringweightlossidentifiesaleptinregulator
_version_	1718386049891172352

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Ejemplares similares