Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction

Author summary Ageing human populations present a huge societal challenge, providing motivation to find ways to improve health in old age. Dietary restriction (DR), is one way to improve late-life health of animals from worms to mammals, and perhaps humans. This effect was first oberved over 80 year...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adam J. Dobson, Xiaoli He, Eric Blanc, Ekin Bolukbasi, Yodit Feseha, Mingyao Yang, Matthew D. W. Piper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5a6103376c014385858bcf0015323dc3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a6103376c014385858bcf0015323dc3
record_format	dspace
spelling	oai:doaj.org-article:5a6103376c014385858bcf0015323dc32021-12-02T14:22:33ZTissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction10.1038/s41514-018-0024-42056-3973https://doaj.org/article/5a6103376c014385858bcf0015323dc32018-04-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0024-4https://doaj.org/toc/2056-3973Author summary Ageing human populations present a huge societal challenge, providing motivation to find ways to improve health in old age. Dietary restriction (DR), is one way to improve late-life health of animals from worms to mammals, and perhaps humans. This effect was first oberved over 80 years ago, but the underlying mechanism has proven elusive. In this study, gene expression was profiled in diverse tissues of flies subjected to DR, and from these results a role for proteins called GATA transcription factors was predicted. Reducing expression of GATA transcription factors altered the effect of diet on lifespan, and targeting this knockdown to specific tissues reduced side-effects commonly associated with longevity. Therefore this study predicts that targeting GATA transcription factors in specific tissues may promote the benefits, but not costs, of DR.Adam J. DobsonXiaoli HeEric BlancEkin BolukbasiYodit FesehaMingyao YangMatthew D. W. PiperNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Adam J. Dobson Xiaoli He Eric Blanc Ekin Bolukbasi Yodit Feseha Mingyao Yang Matthew D. W. Piper Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction
description	Author summary Ageing human populations present a huge societal challenge, providing motivation to find ways to improve health in old age. Dietary restriction (DR), is one way to improve late-life health of animals from worms to mammals, and perhaps humans. This effect was first oberved over 80 years ago, but the underlying mechanism has proven elusive. In this study, gene expression was profiled in diverse tissues of flies subjected to DR, and from these results a role for proteins called GATA transcription factors was predicted. Reducing expression of GATA transcription factors altered the effect of diet on lifespan, and targeting this knockdown to specific tissues reduced side-effects commonly associated with longevity. Therefore this study predicts that targeting GATA transcription factors in specific tissues may promote the benefits, but not costs, of DR.
format	article
author	Adam J. Dobson Xiaoli He Eric Blanc Ekin Bolukbasi Yodit Feseha Mingyao Yang Matthew D. W. Piper
author_facet	Adam J. Dobson Xiaoli He Eric Blanc Ekin Bolukbasi Yodit Feseha Mingyao Yang Matthew D. W. Piper
author_sort	Adam J. Dobson
title	Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction
title_short	Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction
title_full	Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction
title_fullStr	Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction
title_full_unstemmed	Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction
title_sort	tissue-specific transcriptome profiling of drosophila reveals roles for gata transcription factors in longevity by dietary restriction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5a6103376c014385858bcf0015323dc3
work_keys_str_mv	AT adamjdobson tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction AT xiaolihe tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction AT ericblanc tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction AT ekinbolukbasi tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction AT yoditfeseha tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction AT mingyaoyang tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction AT matthewdwpiper tissuespecifictranscriptomeprofilingofdrosophilarevealsrolesforgatatranscriptionfactorsinlongevitybydietaryrestriction
_version_	1718391486725226496

Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction

Ejemplares similares