Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

The transcription factor Hsf1 and the molecular chaperone Hsp90 modulate the heat shock response in the pathogen Candida albicans. Here, Leach et al. reveal a complex interplay between the two factors that regulates the expression of genes involved in the heat shock response and virulence.

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Detalles Bibliográficos
Autores principales: Michelle D. Leach, Rhys A. Farrer, Kaeling Tan, Zhengqiang Miao, Louise A. Walker, Christina A. Cuomo, Robert T. Wheeler, Alistair J. P. Brown, Koon Ho Wong, Leah E. Cowen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/5a61a55cffcb49418d894c6ff91cee45
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Sumario:The transcription factor Hsf1 and the molecular chaperone Hsp90 modulate the heat shock response in the pathogen Candida albicans. Here, Leach et al. reveal a complex interplay between the two factors that regulates the expression of genes involved in the heat shock response and virulence.