Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1, and promotes its deacetylation activity toward nat...

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Autores principales:	Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki, Tomiko Asakura, Kentaro Shimizu, Fumihiko Hakuno, Shin-Ichiro Takahashi, Norimoto Shimada, Jinwei Yang, Tsutomu Ishikawa, Jin Tatsuzaki, Koji Nagata
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5a67ff013a7841da9cbb1ba0d1000592
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spelling	oai:doaj.org-article:5a67ff013a7841da9cbb1ba0d10005922021-12-02T14:21:58ZQuercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT110.1038/s42003-021-01705-12399-3642https://doaj.org/article/5a67ff013a7841da9cbb1ba0d10005922021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01705-1https://doaj.org/toc/2399-3642A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1, and promotes its deacetylation activity toward native substrate more effectively than resveratrol.Mimin ZhangPeng LuTohru TeradaMiaomiao SuiHaruka FurutaKilico IidaYukie KatayamaYi LuKen OkamotoMichio SuzukiTomiko AsakuraKentaro ShimizuFumihiko HakunoShin-Ichiro TakahashiNorimoto ShimadaJinwei YangTsutomu IshikawaJin TatsuzakiKoji NagataNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mimin Zhang Peng Lu Tohru Terada Miaomiao Sui Haruka Furuta Kilico Iida Yukie Katayama Yi Lu Ken Okamoto Michio Suzuki Tomiko Asakura Kentaro Shimizu Fumihiko Hakuno Shin-Ichiro Takahashi Norimoto Shimada Jinwei Yang Tsutomu Ishikawa Jin Tatsuzaki Koji Nagata Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
description	A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1, and promotes its deacetylation activity toward native substrate more effectively than resveratrol.
format	article
author	Mimin Zhang Peng Lu Tohru Terada Miaomiao Sui Haruka Furuta Kilico Iida Yukie Katayama Yi Lu Ken Okamoto Michio Suzuki Tomiko Asakura Kentaro Shimizu Fumihiko Hakuno Shin-Ichiro Takahashi Norimoto Shimada Jinwei Yang Tsutomu Ishikawa Jin Tatsuzaki Koji Nagata
author_facet	Mimin Zhang Peng Lu Tohru Terada Miaomiao Sui Haruka Furuta Kilico Iida Yukie Katayama Yi Lu Ken Okamoto Michio Suzuki Tomiko Asakura Kentaro Shimizu Fumihiko Hakuno Shin-Ichiro Takahashi Norimoto Shimada Jinwei Yang Tsutomu Ishikawa Jin Tatsuzaki Koji Nagata
author_sort	Mimin Zhang
title	Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
title_short	Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
title_full	Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
title_fullStr	Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
title_full_unstemmed	Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
title_sort	quercetin 3,5,7,3′,4′-pentamethyl ether from kaempferia parviflora directly and effectively activates human sirt1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a67ff013a7841da9cbb1ba0d1000592
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Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

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