The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor

F-box proteins β-TrCP1 and SKP2 act as oncogenes by promoting targeted degradation of critical protein substrates. Here, the authors identify an axis of F-box proteins β-TrCP1-FBXW2-SKP2 where FBXW2 is a substrate of β-TrCP1 but mediates the degradation of SKP2, thus acting as a tumour suppressor....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jie Xu, Weihua Zhou, Fei Yang, Guoan Chen, Haomin Li, Yongchao Zhao, Pengyuan Liu, Hua Li, Mingjia Tan, Xiufang Xiong, Yi Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a6a418d610f4a3a894b646c23b48e33
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a6a418d610f4a3a894b646c23b48e33
record_format	dspace
spelling	oai:doaj.org-article:5a6a418d610f4a3a894b646c23b48e332021-12-02T15:37:02ZThe β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor10.1038/ncomms140022041-1723https://doaj.org/article/5a6a418d610f4a3a894b646c23b48e332017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14002https://doaj.org/toc/2041-1723F-box proteins β-TrCP1 and SKP2 act as oncogenes by promoting targeted degradation of critical protein substrates. Here, the authors identify an axis of F-box proteins β-TrCP1-FBXW2-SKP2 where FBXW2 is a substrate of β-TrCP1 but mediates the degradation of SKP2, thus acting as a tumour suppressor.Jie XuWeihua ZhouFei YangGuoan ChenHaomin LiYongchao ZhaoPengyuan LiuHua LiMingjia TanXiufang XiongYi SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Xu Weihua Zhou Fei Yang Guoan Chen Haomin Li Yongchao Zhao Pengyuan Liu Hua Li Mingjia Tan Xiufang Xiong Yi Sun The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
description	F-box proteins β-TrCP1 and SKP2 act as oncogenes by promoting targeted degradation of critical protein substrates. Here, the authors identify an axis of F-box proteins β-TrCP1-FBXW2-SKP2 where FBXW2 is a substrate of β-TrCP1 but mediates the degradation of SKP2, thus acting as a tumour suppressor.
format	article
author	Jie Xu Weihua Zhou Fei Yang Guoan Chen Haomin Li Yongchao Zhao Pengyuan Liu Hua Li Mingjia Tan Xiufang Xiong Yi Sun
author_facet	Jie Xu Weihua Zhou Fei Yang Guoan Chen Haomin Li Yongchao Zhao Pengyuan Liu Hua Li Mingjia Tan Xiufang Xiong Yi Sun
author_sort	Jie Xu
title	The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
title_short	The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
title_full	The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
title_fullStr	The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
title_full_unstemmed	The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
title_sort	β-trcp-fbxw2-skp2 axis regulates lung cancer cell growth with fbxw2 acting as a tumour suppressor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5a6a418d610f4a3a894b646c23b48e33
work_keys_str_mv	AT jiexu thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT weihuazhou thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT feiyang thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT guoanchen thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT haominli thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT yongchaozhao thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT pengyuanliu thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT huali thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT mingjiatan thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT xiufangxiong thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT yisun thebtrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT jiexu btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT weihuazhou btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT feiyang btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT guoanchen btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT haominli btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT yongchaozhao btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT pengyuanliu btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT huali btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT mingjiatan btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT xiufangxiong btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor AT yisun btrcpfbxw2skp2axisregulateslungcancercellgrowthwithfbxw2actingasatumoursuppressor
_version_	1718386234597834752

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor

Ejemplares similares