The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor
F-box proteins β-TrCP1 and SKP2 act as oncogenes by promoting targeted degradation of critical protein substrates. Here, the authors identify an axis of F-box proteins β-TrCP1-FBXW2-SKP2 where FBXW2 is a substrate of β-TrCP1 but mediates the degradation of SKP2, thus acting as a tumour suppressor....
Guardado en:
Autores principales: | Jie Xu, Weihua Zhou, Fei Yang, Guoan Chen, Haomin Li, Yongchao Zhao, Pengyuan Liu, Hua Li, Mingjia Tan, Xiufang Xiong, Yi Sun |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/5a6a418d610f4a3a894b646c23b48e33 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
por: Fei Yang, et al.
Publicado: (2019) -
Role of FBXW2 in explant cultures of bovine periosteum-derived cells
por: Mari Akiyama
Publicado: (2021) -
HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.
por: Bastien Mangeat, et al.
Publicado: (2009) -
Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP
por: Victor V. Tatarskiy, et al.
Publicado: (2017) -
MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal
por: Yan Zhang, et al.
Publicado: (2021)