Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease
Paulina Krawiec, Elżbieta Pac-Kożuchowska Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, PolandCorrespondence: Paulina KrawiecDepartment of Pediatrics and Gastroenterology, Medical University of Lublin, Racławickie 1, Lublin 20-059, PolandTel +48 81 71 85 400Fax...
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Dove Medical Press
2021
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oai:doaj.org-article:5a6c21ed54d74c988c65b769ee8aca392021-12-02T11:50:52ZCathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease1178-7031https://doaj.org/article/5a6c21ed54d74c988c65b769ee8aca392021-01-01T00:00:00Zhttps://www.dovepress.com/cathelicidin-ndash-a-novel-potential-marker-of-pediatric-inflammatory--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Paulina Krawiec, Elżbieta Pac-Kożuchowska Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, PolandCorrespondence: Paulina KrawiecDepartment of Pediatrics and Gastroenterology, Medical University of Lublin, Racławickie 1, Lublin 20-059, PolandTel +48 81 71 85 400Fax +48 81 74 31 353Email paulinakrawiec@umlub.plIntroduction: Cathelicidin is a multifunctional host defense peptide which may also exert pro-inflammatory signals and contribute to the development of autoimmune disorders. We aimed to assess serum concentration of cathelicidin in children with inflammatory bowel disease (IBD) compared to healthy controls and to evaluate its relationship with disease activity and phenotype.Patients and Methods: The study group included 68 children with IBD. The control group comprised 20 children with functional abdominal pain. All patients and controls were tested for complete blood count, C-reactive protein, erythrocyte sedimentation rate and cathelicidin. Stool samples were collected to assess calprotectin.Results: Cathelicidin was significantly increased in patients with ulcerative colitis (1073.39± 214.52 ng/mL) and Crohn’s disease (1057.63± 176.03 ng/mL) patients compared to controls (890.56± 129.37 ng/mL) (H=16.28; p=0.0003). Cathelicidin was significantly elevated in children with active IBD (1044.90± 176.17 ng/mL) and IBD remission (1098.10± 227.87 ng/mL) compared to controls (Z=3.21; p=0.001; Z=− 4.12; p< 0.0001, respectively). Negative correlation between cathelicidin and calprotectin in children with ulcerative colitis was found (R=− 0.39; p=0.02). Cathelicidin exhibited AUC of 0.815 for differentiation children with ulcerative colitis from the control group.Conclusion: Serum cathelicidin is increased in children with Crohn’s disease and ulcerative colitis regardless of clinical activity of the disease suggesting that it may be a potential biomarker of IBD. Inverse correlation between cathelicidin and fecal calprotectin may imply a disparate role of these molecules in the pathophysiology of pediatric ulcerative colitis.Keywords: antibacterial peptides, Crohn’s disease, LL-37, ulcerative colitisKrawiec PPac-Kożuchowska EDove Medical Pressarticleantibacterial peptidescrohn’s diseasell-37ulcerative colitisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 163-174 (2021) |
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DOAJ |
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antibacterial peptides crohn’s disease ll-37 ulcerative colitis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
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antibacterial peptides crohn’s disease ll-37 ulcerative colitis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Krawiec P Pac-Kożuchowska E Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease |
| description |
Paulina Krawiec, Elżbieta Pac-Kożuchowska Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, PolandCorrespondence: Paulina KrawiecDepartment of Pediatrics and Gastroenterology, Medical University of Lublin, Racławickie 1, Lublin 20-059, PolandTel +48 81 71 85 400Fax +48 81 74 31 353Email paulinakrawiec@umlub.plIntroduction: Cathelicidin is a multifunctional host defense peptide which may also exert pro-inflammatory signals and contribute to the development of autoimmune disorders. We aimed to assess serum concentration of cathelicidin in children with inflammatory bowel disease (IBD) compared to healthy controls and to evaluate its relationship with disease activity and phenotype.Patients and Methods: The study group included 68 children with IBD. The control group comprised 20 children with functional abdominal pain. All patients and controls were tested for complete blood count, C-reactive protein, erythrocyte sedimentation rate and cathelicidin. Stool samples were collected to assess calprotectin.Results: Cathelicidin was significantly increased in patients with ulcerative colitis (1073.39± 214.52 ng/mL) and Crohn’s disease (1057.63± 176.03 ng/mL) patients compared to controls (890.56± 129.37 ng/mL) (H=16.28; p=0.0003). Cathelicidin was significantly elevated in children with active IBD (1044.90± 176.17 ng/mL) and IBD remission (1098.10± 227.87 ng/mL) compared to controls (Z=3.21; p=0.001; Z=− 4.12; p< 0.0001, respectively). Negative correlation between cathelicidin and calprotectin in children with ulcerative colitis was found (R=− 0.39; p=0.02). Cathelicidin exhibited AUC of 0.815 for differentiation children with ulcerative colitis from the control group.Conclusion: Serum cathelicidin is increased in children with Crohn’s disease and ulcerative colitis regardless of clinical activity of the disease suggesting that it may be a potential biomarker of IBD. Inverse correlation between cathelicidin and fecal calprotectin may imply a disparate role of these molecules in the pathophysiology of pediatric ulcerative colitis.Keywords: antibacterial peptides, Crohn’s disease, LL-37, ulcerative colitis |
| format |
article |
| author |
Krawiec P Pac-Kożuchowska E |
| author_facet |
Krawiec P Pac-Kożuchowska E |
| author_sort |
Krawiec P |
| title |
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease |
| title_short |
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease |
| title_full |
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease |
| title_fullStr |
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease |
| title_full_unstemmed |
Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease |
| title_sort |
cathelicidin – a novel potential marker of pediatric inflammatory bowel disease |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/5a6c21ed54d74c988c65b769ee8aca39 |
| work_keys_str_mv |
AT krawiecp cathelicidinndashanovelpotentialmarkerofpediatricinflammatoryboweldisease AT packozuchowskae cathelicidinndashanovelpotentialmarkerofpediatricinflammatoryboweldisease |
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