COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this ho...

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Autores principales: Susanne Rysz, Jonathan Al-Saadi, Anna Sjöström, Maria Farm, Francesca Campoccia Jalde, Michael Plattén, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyrén, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5a6e78e3d70b42c2a7c95b1e2fd96085
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Sumario:The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this hormonal system.

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