COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this ho...

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Autores principales:	Susanne Rysz, Jonathan Al-Saadi, Anna Sjöström, Maria Farm, Francesca Campoccia Jalde, Michael Plattén, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyrén, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a6e78e3d70b42c2a7c95b1e2fd96085
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spelling	oai:doaj.org-article:5a6e78e3d70b42c2a7c95b1e2fd960852021-12-02T17:33:40ZCOVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system10.1038/s41467-021-22713-z2041-1723https://doaj.org/article/5a6e78e3d70b42c2a7c95b1e2fd960852021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22713-zhttps://doaj.org/toc/2041-1723The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this hormonal system.Susanne RyszJonathan Al-SaadiAnna SjöströmMaria FarmFrancesca Campoccia JaldeMichael PlatténHelen ErikssonMargareta KleinRoberto Vargas-ParisSven NyrénGoran AbdulaRussell OuelletteTobias GranbergMalin Jonsson FagerlundJohan LundbergNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susanne Rysz Jonathan Al-Saadi Anna Sjöström Maria Farm Francesca Campoccia Jalde Michael Plattén Helen Eriksson Margareta Klein Roberto Vargas-Paris Sven Nyrén Goran Abdula Russell Ouellette Tobias Granberg Malin Jonsson Fagerlund Johan Lundberg COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
description	The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this hormonal system.
format	article
author	Susanne Rysz Jonathan Al-Saadi Anna Sjöström Maria Farm Francesca Campoccia Jalde Michael Plattén Helen Eriksson Margareta Klein Roberto Vargas-Paris Sven Nyrén Goran Abdula Russell Ouellette Tobias Granberg Malin Jonsson Fagerlund Johan Lundberg
author_facet	Susanne Rysz Jonathan Al-Saadi Anna Sjöström Maria Farm Francesca Campoccia Jalde Michael Plattén Helen Eriksson Margareta Klein Roberto Vargas-Paris Sven Nyrén Goran Abdula Russell Ouellette Tobias Granberg Malin Jonsson Fagerlund Johan Lundberg
author_sort	Susanne Rysz
title	COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
title_short	COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
title_full	COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
title_fullStr	COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
title_full_unstemmed	COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
title_sort	covid-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a6e78e3d70b42c2a7c95b1e2fd96085
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COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

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