Multi-resolution localization of causal variants across the genome

GWAS analysis currently relies mostly on linear mixed models, which do not account for linkage disequilibrium (LD) between tested variants. Here, Sesia et al. propose KnockoffZoom, a non-parametric statistical method for the simultaneous discovery and fine-mapping of causal variants, assuming only t...

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Autores principales: Matteo Sesia, Eugene Katsevich, Stephen Bates, Emmanuel Candès, Chiara Sabatti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5a6f10c7c51540a6bf620c7a5cb1956c
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