Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

The functional significance of the observed heterogeneity of androgen receptor (AR) expression in prostate cancer is unknown. Here the authors show AR expression heterogeneity is associated with distinct castration/enzalutamide responses and identify BCL-2 as a potential therapeutic target in castra...

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Autores principales:	Qiuhui Li, Qu Deng, Hsueh-Ping Chao, Xin Liu, Yue Lu, Kevin Lin, Bigang Liu, Gregory W. Tang, Dingxiao Zhang, Amanda Tracz, Collene Jeter, Kiera Rycaj, Tammy Calhoun-Davis, Jiaoti Huang, Mark A. Rubin, Himisha Beltran, Jianjun Shen, Gurkamal Chatta, Igor Puzanov, James L. Mohler, Jianmin Wang, Ruizhe Zhao, Jason Kirk, Xin Chen, Dean G. Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a734dbbd52a444ea8aff078384df83d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5a734dbbd52a444ea8aff078384df83d2021-12-02T15:34:27ZLinking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses10.1038/s41467-018-06067-72041-1723https://doaj.org/article/5a734dbbd52a444ea8aff078384df83d2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06067-7https://doaj.org/toc/2041-1723The functional significance of the observed heterogeneity of androgen receptor (AR) expression in prostate cancer is unknown. Here the authors show AR expression heterogeneity is associated with distinct castration/enzalutamide responses and identify BCL-2 as a potential therapeutic target in castration-resistant prostate cancer.Qiuhui LiQu DengHsueh-Ping ChaoXin LiuYue LuKevin LinBigang LiuGregory W. TangDingxiao ZhangAmanda TraczCollene JeterKiera RycajTammy Calhoun-DavisJiaoti HuangMark A. RubinHimisha BeltranJianjun ShenGurkamal ChattaIgor PuzanovJames L. MohlerJianmin WangRuizhe ZhaoJason KirkXin ChenDean G. TangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiuhui Li Qu Deng Hsueh-Ping Chao Xin Liu Yue Lu Kevin Lin Bigang Liu Gregory W. Tang Dingxiao Zhang Amanda Tracz Collene Jeter Kiera Rycaj Tammy Calhoun-Davis Jiaoti Huang Mark A. Rubin Himisha Beltran Jianjun Shen Gurkamal Chatta Igor Puzanov James L. Mohler Jianmin Wang Ruizhe Zhao Jason Kirk Xin Chen Dean G. Tang Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
description	The functional significance of the observed heterogeneity of androgen receptor (AR) expression in prostate cancer is unknown. Here the authors show AR expression heterogeneity is associated with distinct castration/enzalutamide responses and identify BCL-2 as a potential therapeutic target in castration-resistant prostate cancer.
format	article
author	Qiuhui Li Qu Deng Hsueh-Ping Chao Xin Liu Yue Lu Kevin Lin Bigang Liu Gregory W. Tang Dingxiao Zhang Amanda Tracz Collene Jeter Kiera Rycaj Tammy Calhoun-Davis Jiaoti Huang Mark A. Rubin Himisha Beltran Jianjun Shen Gurkamal Chatta Igor Puzanov James L. Mohler Jianmin Wang Ruizhe Zhao Jason Kirk Xin Chen Dean G. Tang
author_facet	Qiuhui Li Qu Deng Hsueh-Ping Chao Xin Liu Yue Lu Kevin Lin Bigang Liu Gregory W. Tang Dingxiao Zhang Amanda Tracz Collene Jeter Kiera Rycaj Tammy Calhoun-Davis Jiaoti Huang Mark A. Rubin Himisha Beltran Jianjun Shen Gurkamal Chatta Igor Puzanov James L. Mohler Jianmin Wang Ruizhe Zhao Jason Kirk Xin Chen Dean G. Tang
author_sort	Qiuhui Li
title	Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
title_short	Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
title_full	Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
title_fullStr	Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
title_full_unstemmed	Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
title_sort	linking prostate cancer cell ar heterogeneity to distinct castration and enzalutamide responses
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5a734dbbd52a444ea8aff078384df83d
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Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

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