Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity

The toxicity arising from generalised stimulation of T cells restricts applicability of CD137 agonists in cancer immune therapy. Here authors show that a bispecific antibody blocking PD-1 while activating CD137 efficiently restricts T cell activation to the tumour microenvironment, resulting in effi...

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Autores principales:	Yunqian Qiao, Yangmin Qiu, Jie Ding, Nana Luo, Hao Wang, Xiaomin Ling, Jiya Sun, Zhihai Wu, Yisen Wang, Yanpeng Liu, Feifei Guo, Ta Sun, Wanwan Shen, Min Zhang, Dongdong Wu, Bingliang Chen, Wei Xu, Xuan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a74607a784c4173b05f771b90d4abb5
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spelling	oai:doaj.org-article:5a74607a784c4173b05f771b90d4abb52021-11-08T11:08:57ZCancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity10.1038/s41467-021-26645-62041-1723https://doaj.org/article/5a74607a784c4173b05f771b90d4abb52021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26645-6https://doaj.org/toc/2041-1723The toxicity arising from generalised stimulation of T cells restricts applicability of CD137 agonists in cancer immune therapy. Here authors show that a bispecific antibody blocking PD-1 while activating CD137 efficiently restricts T cell activation to the tumour microenvironment, resulting in efficient tumour control and reduced liver toxicity.Yunqian QiaoYangmin QiuJie DingNana LuoHao WangXiaomin LingJiya SunZhihai WuYisen WangYanpeng LiuFeifei GuoTa SunWanwan ShenMin ZhangDongdong WuBingliang ChenWei XuXuan WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunqian Qiao Yangmin Qiu Jie Ding Nana Luo Hao Wang Xiaomin Ling Jiya Sun Zhihai Wu Yisen Wang Yanpeng Liu Feifei Guo Ta Sun Wanwan Shen Min Zhang Dongdong Wu Bingliang Chen Wei Xu Xuan Wang Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
description	The toxicity arising from generalised stimulation of T cells restricts applicability of CD137 agonists in cancer immune therapy. Here authors show that a bispecific antibody blocking PD-1 while activating CD137 efficiently restricts T cell activation to the tumour microenvironment, resulting in efficient tumour control and reduced liver toxicity.
format	article
author	Yunqian Qiao Yangmin Qiu Jie Ding Nana Luo Hao Wang Xiaomin Ling Jiya Sun Zhihai Wu Yisen Wang Yanpeng Liu Feifei Guo Ta Sun Wanwan Shen Min Zhang Dongdong Wu Bingliang Chen Wei Xu Xuan Wang
author_facet	Yunqian Qiao Yangmin Qiu Jie Ding Nana Luo Hao Wang Xiaomin Ling Jiya Sun Zhihai Wu Yisen Wang Yanpeng Liu Feifei Guo Ta Sun Wanwan Shen Min Zhang Dongdong Wu Bingliang Chen Wei Xu Xuan Wang
author_sort	Yunqian Qiao
title	Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
title_short	Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
title_full	Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
title_fullStr	Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
title_full_unstemmed	Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity
title_sort	cancer immune therapy with pd-1-dependent cd137 co-stimulation provides localized tumour killing without systemic toxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a74607a784c4173b05f771b90d4abb5
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Cancer immune therapy with PD-1-dependent CD137 co-stimulation provides localized tumour killing without systemic toxicity

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