Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling.

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Autores principales:	Fatemeh Mirzamohammadi, Garyfallia Papaioannou, Jennifer B. Inloes, Erinn B. Rankin, Huafeng Xie, Ernestina Schipani, Stuart H. Orkin, Tatsuya Kobayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a75c493278c44bfa5a6dabee56bba1b
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spelling	oai:doaj.org-article:5a75c493278c44bfa5a6dabee56bba1b2021-12-02T17:32:38ZPolycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling10.1038/ncomms120472041-1723https://doaj.org/article/5a75c493278c44bfa5a6dabee56bba1b2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12047https://doaj.org/toc/2041-1723Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling.Fatemeh MirzamohammadiGaryfallia PapaioannouJennifer B. InloesErinn B. RankinHuafeng XieErnestina SchipaniStuart H. OrkinTatsuya KobayashiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fatemeh Mirzamohammadi Garyfallia Papaioannou Jennifer B. Inloes Erinn B. Rankin Huafeng Xie Ernestina Schipani Stuart H. Orkin Tatsuya Kobayashi Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
description	Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling.
format	article
author	Fatemeh Mirzamohammadi Garyfallia Papaioannou Jennifer B. Inloes Erinn B. Rankin Huafeng Xie Ernestina Schipani Stuart H. Orkin Tatsuya Kobayashi
author_facet	Fatemeh Mirzamohammadi Garyfallia Papaioannou Jennifer B. Inloes Erinn B. Rankin Huafeng Xie Ernestina Schipani Stuart H. Orkin Tatsuya Kobayashi
author_sort	Fatemeh Mirzamohammadi
title	Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
title_short	Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
title_full	Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
title_fullStr	Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
title_full_unstemmed	Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling
title_sort	polycomb repressive complex 2 regulates skeletal growth by suppressing wnt and tgf-β signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5a75c493278c44bfa5a6dabee56bba1b
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Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

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