Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling.

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Autores principales: Fatemeh Mirzamohammadi, Garyfallia Papaioannou, Jennifer B. Inloes, Erinn B. Rankin, Huafeng Xie, Ernestina Schipani, Stuart H. Orkin, Tatsuya Kobayashi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/5a75c493278c44bfa5a6dabee56bba1b
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