Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer

Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.

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Autores principales: Rueyhung R. Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/5a791e731bc34d978ebea8a2c82ef6e8
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spelling oai:doaj.org-article:5a791e731bc34d978ebea8a2c82ef6e82021-12-02T14:25:15ZEpigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer10.1038/s41467-021-22433-42041-1723https://doaj.org/article/5a791e731bc34d978ebea8a2c82ef6e82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22433-4https://doaj.org/toc/2041-1723Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.Rueyhung R. WengHsuan-Hsuan LuChien-Ting LinChia-Chi FanRong-Shan LinTai-Chung HuangShu-Yung LinYi-Jhen HuangYi-Hsiu JuanYi-Chieh WuZheng-Ci HungChi LiuXuan-Hui LinWan-Chen HsiehTzu-Yuan ChiuJung-Chi LiaoYen-Ling ChiuShih-Yu ChenChong-Jen YuHsing-Chen TsaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rueyhung R. Weng
Hsuan-Hsuan Lu
Chien-Ting Lin
Chia-Chi Fan
Rong-Shan Lin
Tai-Chung Huang
Shu-Yung Lin
Yi-Jhen Huang
Yi-Hsiu Juan
Yi-Chieh Wu
Zheng-Ci Hung
Chi Liu
Xuan-Hui Lin
Wan-Chen Hsieh
Tzu-Yuan Chiu
Jung-Chi Liao
Yen-Ling Chiu
Shih-Yu Chen
Chong-Jen Yu
Hsing-Chen Tsai
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
description Gamma delta (γδ) T cells have potential for use in immunotherapy against tumours. Here, the authors demonstrate that treatment of tumours with DNA methyltransferase inhibitors modulates cytoskeleton arrangements, upregulates adhesion molecules and increases tumour killing by γδ T cells.
format article
author Rueyhung R. Weng
Hsuan-Hsuan Lu
Chien-Ting Lin
Chia-Chi Fan
Rong-Shan Lin
Tai-Chung Huang
Shu-Yung Lin
Yi-Jhen Huang
Yi-Hsiu Juan
Yi-Chieh Wu
Zheng-Ci Hung
Chi Liu
Xuan-Hui Lin
Wan-Chen Hsieh
Tzu-Yuan Chiu
Jung-Chi Liao
Yen-Ling Chiu
Shih-Yu Chen
Chong-Jen Yu
Hsing-Chen Tsai
author_facet Rueyhung R. Weng
Hsuan-Hsuan Lu
Chien-Ting Lin
Chia-Chi Fan
Rong-Shan Lin
Tai-Chung Huang
Shu-Yung Lin
Yi-Jhen Huang
Yi-Hsiu Juan
Yi-Chieh Wu
Zheng-Ci Hung
Chi Liu
Xuan-Hui Lin
Wan-Chen Hsieh
Tzu-Yuan Chiu
Jung-Chi Liao
Yen-Ling Chiu
Shih-Yu Chen
Chong-Jen Yu
Hsing-Chen Tsai
author_sort Rueyhung R. Weng
title Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
title_short Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
title_full Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
title_fullStr Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
title_full_unstemmed Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer
title_sort epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ t cell-mediated cytotoxicity in lung cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5a791e731bc34d978ebea8a2c82ef6e8
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