Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats

Ingrid Delbone Figueiredo, Tayra Ferreira Oliveira Lima, Maiara Destro Inácio, Mariana Campos Costa, Renata Pires Assis, Iguatemy Lourenço Brunetti, Amanda Martins Baviera Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University...

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Autores principales:	Figueiredo ID, Lima TFO, Inácio MD, Costa MC, Assis RP, Brunetti IL, Baviera AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetes mellitus combined therapy lycopene paraoxonase glycoxidative stress Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5a7eec2be07f482aa4faa9eae9749ef7
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spelling	oai:doaj.org-article:5a7eec2be07f482aa4faa9eae9749ef72021-12-02T11:00:52ZLycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats1178-7007https://doaj.org/article/5a7eec2be07f482aa4faa9eae9749ef72020-09-01T00:00:00Zhttps://www.dovepress.com/lycopene-improves-the-metformin-effects-on-glycemic-control-and-decrea-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ingrid Delbone Figueiredo, Tayra Ferreira Oliveira Lima, Maiara Destro Inácio, Mariana Campos Costa, Renata Pires Assis, Iguatemy Lourenço Brunetti, Amanda Martins Baviera Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (Unesp), Araraquara, São Paulo, BrazilCorrespondence: Amanda Martins Baviera Department of Clinical AnalysisSchool of Pharmaceutical Sciences, São Paulo State University Rodovia Araraquara Jaú, Km 01 – s/n, Campos Ville, Araraquara, São Paulo CEP 14800-903, BrazilTel +55 16 3301 5717Fax +55 16 3322 0073Email amanda.baviera@unesp.brIntroduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability to mitigate diabetic disturbances, including the deleterious events of advanced glycation. Therefore, this carotenoid has emerged as a candidate to be used in combination with antidiabetic drugs, such as metformin, attempting to counteract the glycoxidative stress. This study investigated the effects of the treatments with lycopene or metformin, alone or in combination, on glycoxidative stress biomarkers and antioxidant defenses in diabetic rats.Methods: Streptozotocin-induced diabetic rats were treated for 35 days with lycopene (45 mg/kg) or metformin (250 mg/kg), alone or as mixtures in yoghurt. Plasma levels of glucose, triglycerides, cholesterol, thiobarbituric acid reactive substances and protein carbonyl groups (biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 activity (antioxidant enzyme) were assessed. Changes in the hepatic and renal levels of glycoxidative damage biomarkers and the activities of antioxidant enzymes were investigated.Results: The combination of lycopene with metformin maintained the beneficial effects of the isolated treatments, improving the glucose tolerance and lipid profile, lessening biomarkers of oxidative damage, and increasing the paraoxonase 1 activity. Besides, the combined therapy caused further decreases in postprandial glycemia, plasma levels of cholesterol and AGEs, avoided lipid peroxidation (plasma, kidney), and increased antioxidant defenses, mainly the activity of superoxide dismutase (liver, kidney), indicating the maintenance of the lycopene effects.Conclusion: Lycopene combined with metformin may act synergistically in the control of postprandial glycemia, dyslipidemia and glycoxidative stress, as well as increased antioxidant defenses, arising as a promising therapeutic strategy to mitigate diabetic complications.Keywords: diabetes mellitus, combined therapy, lycopene, paraoxonase, glycoxidative stressFigueiredo IDLima TFOInácio MDCosta MCAssis RPBrunetti ILBaviera AMDove Medical Pressarticlediabetes mellituscombined therapylycopeneparaoxonaseglycoxidative stressSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3117-3135 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus combined therapy lycopene paraoxonase glycoxidative stress Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus combined therapy lycopene paraoxonase glycoxidative stress Specialties of internal medicine RC581-951 Figueiredo ID Lima TFO Inácio MD Costa MC Assis RP Brunetti IL Baviera AM Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
description	Ingrid Delbone Figueiredo, Tayra Ferreira Oliveira Lima, Maiara Destro Inácio, Mariana Campos Costa, Renata Pires Assis, Iguatemy Lourenço Brunetti, Amanda Martins Baviera Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (Unesp), Araraquara, São Paulo, BrazilCorrespondence: Amanda Martins Baviera Department of Clinical AnalysisSchool of Pharmaceutical Sciences, São Paulo State University Rodovia Araraquara Jaú, Km 01 – s/n, Campos Ville, Araraquara, São Paulo CEP 14800-903, BrazilTel +55 16 3301 5717Fax +55 16 3322 0073Email amanda.baviera@unesp.brIntroduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability to mitigate diabetic disturbances, including the deleterious events of advanced glycation. Therefore, this carotenoid has emerged as a candidate to be used in combination with antidiabetic drugs, such as metformin, attempting to counteract the glycoxidative stress. This study investigated the effects of the treatments with lycopene or metformin, alone or in combination, on glycoxidative stress biomarkers and antioxidant defenses in diabetic rats.Methods: Streptozotocin-induced diabetic rats were treated for 35 days with lycopene (45 mg/kg) or metformin (250 mg/kg), alone or as mixtures in yoghurt. Plasma levels of glucose, triglycerides, cholesterol, thiobarbituric acid reactive substances and protein carbonyl groups (biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 activity (antioxidant enzyme) were assessed. Changes in the hepatic and renal levels of glycoxidative damage biomarkers and the activities of antioxidant enzymes were investigated.Results: The combination of lycopene with metformin maintained the beneficial effects of the isolated treatments, improving the glucose tolerance and lipid profile, lessening biomarkers of oxidative damage, and increasing the paraoxonase 1 activity. Besides, the combined therapy caused further decreases in postprandial glycemia, plasma levels of cholesterol and AGEs, avoided lipid peroxidation (plasma, kidney), and increased antioxidant defenses, mainly the activity of superoxide dismutase (liver, kidney), indicating the maintenance of the lycopene effects.Conclusion: Lycopene combined with metformin may act synergistically in the control of postprandial glycemia, dyslipidemia and glycoxidative stress, as well as increased antioxidant defenses, arising as a promising therapeutic strategy to mitigate diabetic complications.Keywords: diabetes mellitus, combined therapy, lycopene, paraoxonase, glycoxidative stress
format	article
author	Figueiredo ID Lima TFO Inácio MD Costa MC Assis RP Brunetti IL Baviera AM
author_facet	Figueiredo ID Lima TFO Inácio MD Costa MC Assis RP Brunetti IL Baviera AM
author_sort	Figueiredo ID
title	Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
title_short	Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
title_full	Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
title_fullStr	Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
title_full_unstemmed	Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
title_sort	lycopene improves the metformin effects on glycemic control and decreases biomarkers of glycoxidative stress in diabetic rats
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5a7eec2be07f482aa4faa9eae9749ef7
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Lycopene Improves the Metformin Effects on Glycemic Control and Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats

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