Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells

Abstract Developing more mature cardiomyocytes derived from human induced pluripotent stem cells is essential for cell transplantation and drug screening. In a previous study, we described a platform on which cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) formed three-d...

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Autores principales:	Lu Zhang, Junjun Li, Li Liu, Chao Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a80cd98dcb741feabe38fa4a4232d6e
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spelling	oai:doaj.org-article:5a80cd98dcb741feabe38fa4a4232d6e2021-12-02T14:04:40ZAnalysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells10.1038/s41598-020-59803-92045-2322https://doaj.org/article/5a80cd98dcb741feabe38fa4a4232d6e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-59803-9https://doaj.org/toc/2045-2322Abstract Developing more mature cardiomyocytes derived from human induced pluripotent stem cells is essential for cell transplantation and drug screening. In a previous study, we described a platform on which cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) formed three-dimensional self-organized tissue rings. Within these rings, traveling waves of action potentials spontaneously originate and propagate for a long time. In order to understand the dynamic behavior of these waves, we developed a mathematical model for the circulation of the electrical signal in such rings. By using the restitution curves of the action potential and the conduction velocity we demonstrated the mechanisms underlying the steady circulation and the features dependent on velocity. The analytic result agreed well with the experimental data in the origination, propagation, and long-term behavior of traveling waves within self-organized tissue rings. The theoretical analysis of traveling waves may also provide a reference to the analysis of reentrant rhythms in hearts.Lu ZhangJunjun LiLi LiuChao TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lu Zhang Junjun Li Li Liu Chao Tang Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
description	Abstract Developing more mature cardiomyocytes derived from human induced pluripotent stem cells is essential for cell transplantation and drug screening. In a previous study, we described a platform on which cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) formed three-dimensional self-organized tissue rings. Within these rings, traveling waves of action potentials spontaneously originate and propagate for a long time. In order to understand the dynamic behavior of these waves, we developed a mathematical model for the circulation of the electrical signal in such rings. By using the restitution curves of the action potential and the conduction velocity we demonstrated the mechanisms underlying the steady circulation and the features dependent on velocity. The analytic result agreed well with the experimental data in the origination, propagation, and long-term behavior of traveling waves within self-organized tissue rings. The theoretical analysis of traveling waves may also provide a reference to the analysis of reentrant rhythms in hearts.
format	article
author	Lu Zhang Junjun Li Li Liu Chao Tang
author_facet	Lu Zhang Junjun Li Li Liu Chao Tang
author_sort	Lu Zhang
title	Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
title_short	Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
title_full	Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
title_fullStr	Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
title_full_unstemmed	Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells
title_sort	analysis of circulating waves in tissue rings derived from human induced pluripotent stem cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5a80cd98dcb741feabe38fa4a4232d6e
work_keys_str_mv	AT luzhang analysisofcirculatingwavesintissueringsderivedfromhumaninducedpluripotentstemcells AT junjunli analysisofcirculatingwavesintissueringsderivedfromhumaninducedpluripotentstemcells AT liliu analysisofcirculatingwavesintissueringsderivedfromhumaninducedpluripotentstemcells AT chaotang analysisofcirculatingwavesintissueringsderivedfromhumaninducedpluripotentstemcells
_version_	1718392022121840640

Analysis of Circulating Waves in Tissue Rings derived from Human Induced Pluripotent Stem Cells

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