Tissue Distribution of the MERS-Coronavirus Receptor in Bats

Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromeda...

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Autores principales:	W. Widagdo, Lineke Begeman, Debby Schipper, Peter R. van Run, Andrew A. Cunningham, Nils Kley, Chantal B. Reusken, Bart L. Haagmans, Judith M. A. van den Brand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a815df3b8c9476b851633d0aac48468
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spelling	oai:doaj.org-article:5a815df3b8c9476b851633d0aac484682021-12-02T15:05:35ZTissue Distribution of the MERS-Coronavirus Receptor in Bats10.1038/s41598-017-01290-62045-2322https://doaj.org/article/5a815df3b8c9476b851633d0aac484682017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01290-6https://doaj.org/toc/2045-2322Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.W. WidagdoLineke BegemanDebby SchipperPeter R. van RunAndrew A. CunninghamNils KleyChantal B. ReuskenBart L. HaagmansJudith M. A. van den BrandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W. Widagdo Lineke Begeman Debby Schipper Peter R. van Run Andrew A. Cunningham Nils Kley Chantal B. Reusken Bart L. Haagmans Judith M. A. van den Brand Tissue Distribution of the MERS-Coronavirus Receptor in Bats
description	Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs. In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus). In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans. In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent. The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route. Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.
format	article
author	W. Widagdo Lineke Begeman Debby Schipper Peter R. van Run Andrew A. Cunningham Nils Kley Chantal B. Reusken Bart L. Haagmans Judith M. A. van den Brand
author_facet	W. Widagdo Lineke Begeman Debby Schipper Peter R. van Run Andrew A. Cunningham Nils Kley Chantal B. Reusken Bart L. Haagmans Judith M. A. van den Brand
author_sort	W. Widagdo
title	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
title_short	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
title_full	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
title_fullStr	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
title_full_unstemmed	Tissue Distribution of the MERS-Coronavirus Receptor in Bats
title_sort	tissue distribution of the mers-coronavirus receptor in bats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5a815df3b8c9476b851633d0aac48468
work_keys_str_mv	AT wwidagdo tissuedistributionofthemerscoronavirusreceptorinbats AT linekebegeman tissuedistributionofthemerscoronavirusreceptorinbats AT debbyschipper tissuedistributionofthemerscoronavirusreceptorinbats AT peterrvanrun tissuedistributionofthemerscoronavirusreceptorinbats AT andrewacunningham tissuedistributionofthemerscoronavirusreceptorinbats AT nilskley tissuedistributionofthemerscoronavirusreceptorinbats AT chantalbreusken tissuedistributionofthemerscoronavirusreceptorinbats AT bartlhaagmans tissuedistributionofthemerscoronavirusreceptorinbats AT judithmavandenbrand tissuedistributionofthemerscoronavirusreceptorinbats
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Tissue Distribution of the MERS-Coronavirus Receptor in Bats

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