C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and upon deletion in mice, causes defective chromo...

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Autores principales:	Laura Gómez-H, Natalia Felipe-Medina, Manuel Sánchez-Martín, Owen R. Davies, Isabel Ramos, Ignacio García-Tuñón, Dirk G. de Rooij, Ihsan Dereli, Attila Tóth, José Luis Barbero, Ricardo Benavente, Elena Llano, Alberto M. Pendas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a816d0aaec44215a0dd259f498219bc
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spelling	oai:doaj.org-article:5a816d0aaec44215a0dd259f498219bc2021-12-02T17:33:06ZC14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility10.1038/ncomms132982041-1723https://doaj.org/article/5a816d0aaec44215a0dd259f498219bc2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13298https://doaj.org/toc/2041-1723The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and upon deletion in mice, causes defective chromosome synapsis and infertility.Laura Gómez-HNatalia Felipe-MedinaManuel Sánchez-MartínOwen R. DaviesIsabel RamosIgnacio García-TuñónDirk G. de RooijIhsan DereliAttila TóthJosé Luis BarberoRicardo BenaventeElena LlanoAlberto M. PendasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Gómez-H Natalia Felipe-Medina Manuel Sánchez-Martín Owen R. Davies Isabel Ramos Ignacio García-Tuñón Dirk G. de Rooij Ihsan Dereli Attila Tóth José Luis Barbero Ricardo Benavente Elena Llano Alberto M. Pendas C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
description	The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and upon deletion in mice, causes defective chromosome synapsis and infertility.
format	article
author	Laura Gómez-H Natalia Felipe-Medina Manuel Sánchez-Martín Owen R. Davies Isabel Ramos Ignacio García-Tuñón Dirk G. de Rooij Ihsan Dereli Attila Tóth José Luis Barbero Ricardo Benavente Elena Llano Alberto M. Pendas
author_facet	Laura Gómez-H Natalia Felipe-Medina Manuel Sánchez-Martín Owen R. Davies Isabel Ramos Ignacio García-Tuñón Dirk G. de Rooij Ihsan Dereli Attila Tóth José Luis Barbero Ricardo Benavente Elena Llano Alberto M. Pendas
author_sort	Laura Gómez-H
title	C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
title_short	C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
title_full	C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
title_fullStr	C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
title_full_unstemmed	C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
title_sort	c14orf39/six6os1 is a constituent of the synaptonemal complex and is essential for mouse fertility
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5a816d0aaec44215a0dd259f498219bc
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C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

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