Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study
Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magne...
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2021
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oai:doaj.org-article:5a818b27e2964c0299710b74f78736782021-11-25T18:01:17ZClinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study10.3390/jcm102252782077-0383https://doaj.org/article/5a818b27e2964c0299710b74f78736782021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5278https://doaj.org/toc/2077-0383Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR). Of these, 119 patients had serum lactate levels > 2.5 mmol/L on admission (high serum lactate group), whereas 241 patients had serum lactate levels ≤ 2.5 mmol/L (low serum lactate group). We compared the myocardial infarct size assessed by CMR between the two groups and performed inverse probability of treatment weighting (IPTW). In CMR analysis, myocardial infarct size was significantly greater in the high serum lactate group than in the low serum lactate group (22.0 ± 11.4% in the high serum lactate group vs. 18.9 ± 10.5% in the low serum lactate group; <i>p</i> = 0.011). The result was consistent after IPTW adjustment (21.5 ± 11.1% vs. 19.2 ± 10.4%; <i>p</i> = 0.044). In multivariate analysis, high serum lactate was associated with larger myocardial infarct (odds ratio 1.59; 95% confidence interval 1.00–2.51; <i>p</i> = 0.048). High serum lactate could predict advanced myocardial injury in AMI patients undergoing PCI.Ik Hyun ParkHyun Kyu ChoJu Hyeon OhWoo Jung ChunYong Hwan ParkMirae LeeMin Sun KimKi Hong ChoiJihoon KimYoung Bin SongJoo-Yong HahnSeung-Hyuk ChoiSang-Chol LeeHyeon-Cheol GwonYeon Hyeon ChoeWoo Jin JangMDPI AGarticleacute myocardial infarctionserum lactatepercutaneous coronary interventionmagnetic resonance imagingMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5278, p 5278 (2021) |
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acute myocardial infarction serum lactate percutaneous coronary intervention magnetic resonance imaging Medicine R |
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acute myocardial infarction serum lactate percutaneous coronary intervention magnetic resonance imaging Medicine R Ik Hyun Park Hyun Kyu Cho Ju Hyeon Oh Woo Jung Chun Yong Hwan Park Mirae Lee Min Sun Kim Ki Hong Choi Jihoon Kim Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Sang-Chol Lee Hyeon-Cheol Gwon Yeon Hyeon Choe Woo Jin Jang Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study |
| description |
Little is known about causality and the pathological mechanism underlying the association of serum lactate with myocardial injury in patients with acute myocardial infarction (AMI). We evaluated data from 360 AMI patients undergoing percutaneous coronary intervention (PCI) using cardiovascular magnetic resonance imaging (CMR). Of these, 119 patients had serum lactate levels > 2.5 mmol/L on admission (high serum lactate group), whereas 241 patients had serum lactate levels ≤ 2.5 mmol/L (low serum lactate group). We compared the myocardial infarct size assessed by CMR between the two groups and performed inverse probability of treatment weighting (IPTW). In CMR analysis, myocardial infarct size was significantly greater in the high serum lactate group than in the low serum lactate group (22.0 ± 11.4% in the high serum lactate group vs. 18.9 ± 10.5% in the low serum lactate group; <i>p</i> = 0.011). The result was consistent after IPTW adjustment (21.5 ± 11.1% vs. 19.2 ± 10.4%; <i>p</i> = 0.044). In multivariate analysis, high serum lactate was associated with larger myocardial infarct (odds ratio 1.59; 95% confidence interval 1.00–2.51; <i>p</i> = 0.048). High serum lactate could predict advanced myocardial injury in AMI patients undergoing PCI. |
| format |
article |
| author |
Ik Hyun Park Hyun Kyu Cho Ju Hyeon Oh Woo Jung Chun Yong Hwan Park Mirae Lee Min Sun Kim Ki Hong Choi Jihoon Kim Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Sang-Chol Lee Hyeon-Cheol Gwon Yeon Hyeon Choe Woo Jin Jang |
| author_facet |
Ik Hyun Park Hyun Kyu Cho Ju Hyeon Oh Woo Jung Chun Yong Hwan Park Mirae Lee Min Sun Kim Ki Hong Choi Jihoon Kim Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Sang-Chol Lee Hyeon-Cheol Gwon Yeon Hyeon Choe Woo Jin Jang |
| author_sort |
Ik Hyun Park |
| title |
Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study |
| title_short |
Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study |
| title_full |
Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study |
| title_fullStr |
Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study |
| title_full_unstemmed |
Clinical Significance of Serum Lactate in Acute Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study |
| title_sort |
clinical significance of serum lactate in acute myocardial infarction: a cardiac magnetic resonance imaging study |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/5a818b27e2964c0299710b74f7873678 |
| work_keys_str_mv |
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