Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review

Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to t...

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Autores principales:	Bruna Costa, Guillermo Martínez-de-Tejada, Paula A. C. Gomes, M. Cristina L. Martins, Fabíola Costa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	orthopedic implant-related infections antimicrobial-peptides (AMPs) surface functionalization peptide immobilization peptide release antimicrobial Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/5a81fa33165f431f9517f05e1c328bfc
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spelling	oai:doaj.org-article:5a81fa33165f431f9517f05e1c328bfc2021-11-25T18:41:49ZAntimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review10.3390/pharmaceutics131119181999-4923https://doaj.org/article/5a81fa33165f431f9517f05e1c328bfc2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1918https://doaj.org/toc/1999-4923Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising substitutes of conventional antibiotics, owing to their broad-spectrum of activity, high efficacy at very low concentrations, and, importantly, low propensity for inducing resistance. The aim of this review is to offer an updated perspective of the development of AMPs-based preventive strategies for orthopedic and dental implant-related infections. In this regard, two major research strategies are herein addressed, namely (i) AMP-releasing systems from titanium-modified surfaces and from bone cements or beads; and (ii) AMP immobilization strategies used to graft AMPs onto titanium or other model surfaces with potential translation as coatings. In overview, releasing strategies have evolved to guarantee higher loadings, prolonged and targeted delivery periods upon infection. In addition, avant-garde self-assembling strategies or polymer brushes allowed higher immobilized peptide surface densities, overcoming bioavailability issues. Future research efforts should focus on the regulatory demands for pre-clinical and clinical validation towards clinical translation.Bruna CostaGuillermo Martínez-de-TejadaPaula A. C. GomesM. Cristina L. MartinsFabíola CostaMDPI AGarticleorthopedic implant-related infectionsantimicrobial-peptides (AMPs)surface functionalizationpeptide immobilizationpeptide releaseantimicrobialPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1918, p 1918 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	orthopedic implant-related infections antimicrobial-peptides (AMPs) surface functionalization peptide immobilization peptide release antimicrobial Pharmacy and materia medica RS1-441
spellingShingle	orthopedic implant-related infections antimicrobial-peptides (AMPs) surface functionalization peptide immobilization peptide release antimicrobial Pharmacy and materia medica RS1-441 Bruna Costa Guillermo Martínez-de-Tejada Paula A. C. Gomes M. Cristina L. Martins Fabíola Costa Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review
description	Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insufficient, and infection prevalence may rise due to the dissemination of antibiotic resistance. Antimicrobial peptides (AMPs) have attracted attention as promising substitutes of conventional antibiotics, owing to their broad-spectrum of activity, high efficacy at very low concentrations, and, importantly, low propensity for inducing resistance. The aim of this review is to offer an updated perspective of the development of AMPs-based preventive strategies for orthopedic and dental implant-related infections. In this regard, two major research strategies are herein addressed, namely (i) AMP-releasing systems from titanium-modified surfaces and from bone cements or beads; and (ii) AMP immobilization strategies used to graft AMPs onto titanium or other model surfaces with potential translation as coatings. In overview, releasing strategies have evolved to guarantee higher loadings, prolonged and targeted delivery periods upon infection. In addition, avant-garde self-assembling strategies or polymer brushes allowed higher immobilized peptide surface densities, overcoming bioavailability issues. Future research efforts should focus on the regulatory demands for pre-clinical and clinical validation towards clinical translation.
format	article
author	Bruna Costa Guillermo Martínez-de-Tejada Paula A. C. Gomes M. Cristina L. Martins Fabíola Costa
author_facet	Bruna Costa Guillermo Martínez-de-Tejada Paula A. C. Gomes M. Cristina L. Martins Fabíola Costa
author_sort	Bruna Costa
title	Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review
title_short	Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review
title_full	Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review
title_fullStr	Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review
title_full_unstemmed	Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review
title_sort	antimicrobial peptides in the battle against orthopedic implant-related infections: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5a81fa33165f431f9517f05e1c328bfc
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Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review

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