Serologic vaccination response after solid organ transplantation: a systematic review.

<h4>Background</h4>Infectious diseases after solid organ transplantation (SOT) are one of the major complications in transplantation medicine. Vaccination-based prevention is desirable, but data on the response to active vaccination after SOT are conflicting.<h4>Methods</h4>I...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Isabella Eckerle, Kerstin Daniela Rosenberger, Marcel Zwahlen, Thomas Junghanss
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a84fe63223c4aeaa613f3e8dc8e7a0b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a84fe63223c4aeaa613f3e8dc8e7a0b
record_format	dspace
spelling	oai:doaj.org-article:5a84fe63223c4aeaa613f3e8dc8e7a0b2021-11-18T07:56:22ZSerologic vaccination response after solid organ transplantation: a systematic review.1932-620310.1371/journal.pone.0056974https://doaj.org/article/5a84fe63223c4aeaa613f3e8dc8e7a0b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23451126/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Infectious diseases after solid organ transplantation (SOT) are one of the major complications in transplantation medicine. Vaccination-based prevention is desirable, but data on the response to active vaccination after SOT are conflicting.<h4>Methods</h4>In this systematic review, we identify the serologic response rate of SOT recipients to post-transplantation vaccination against tetanus, diphtheria, polio, hepatitis A and B, influenza, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitides, tick-borne encephalitis, rabies, varicella, mumps, measles, and rubella.<h4>Results</h4>Of the 2478 papers initially identified, 72 were included in the final review. The most important findings are that (1) most clinical trials conducted and published over more than 30 years have all been small and highly heterogeneous regarding trial design, patient cohorts selected, patient inclusion criteria, dosing and vaccination schemes, follow up periods and outcomes assessed, (2) the individual vaccines investigated have been studied predominately only in one group of SOT recipients, i.e. tetanus, diphtheria and polio in RTX recipients, hepatitis A exclusively in adult LTX recipients and mumps, measles and rubella in paediatric LTX recipients, (3) SOT recipients mount an immune response which is for most vaccines lower than in healthy controls. The degree to which this response is impaired varies with the type of vaccine, age and organ transplanted and (4) for some vaccines antibodies decline rapidly.<h4>Conclusion</h4>Vaccine-based prevention of infectious diseases is far from satisfactory in SOT recipients. Despite the large number of vaccination studies preformed over the past decades, knowledge on vaccination response is still limited. Even though the protection, which can be achieved in SOT recipients through vaccination, appears encouraging on the basis of available data, current vaccination guidelines and recommendations for post-SOT recipients remain poorly supported by evidence. There is an urgent need to conduct appropriately powered vaccination trials in well-defined SOT recipient cohorts.Isabella EckerleKerstin Daniela RosenbergerMarcel ZwahlenThomas JunghanssPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56974 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabella Eckerle Kerstin Daniela Rosenberger Marcel Zwahlen Thomas Junghanss Serologic vaccination response after solid organ transplantation: a systematic review.
description	<h4>Background</h4>Infectious diseases after solid organ transplantation (SOT) are one of the major complications in transplantation medicine. Vaccination-based prevention is desirable, but data on the response to active vaccination after SOT are conflicting.<h4>Methods</h4>In this systematic review, we identify the serologic response rate of SOT recipients to post-transplantation vaccination against tetanus, diphtheria, polio, hepatitis A and B, influenza, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitides, tick-borne encephalitis, rabies, varicella, mumps, measles, and rubella.<h4>Results</h4>Of the 2478 papers initially identified, 72 were included in the final review. The most important findings are that (1) most clinical trials conducted and published over more than 30 years have all been small and highly heterogeneous regarding trial design, patient cohorts selected, patient inclusion criteria, dosing and vaccination schemes, follow up periods and outcomes assessed, (2) the individual vaccines investigated have been studied predominately only in one group of SOT recipients, i.e. tetanus, diphtheria and polio in RTX recipients, hepatitis A exclusively in adult LTX recipients and mumps, measles and rubella in paediatric LTX recipients, (3) SOT recipients mount an immune response which is for most vaccines lower than in healthy controls. The degree to which this response is impaired varies with the type of vaccine, age and organ transplanted and (4) for some vaccines antibodies decline rapidly.<h4>Conclusion</h4>Vaccine-based prevention of infectious diseases is far from satisfactory in SOT recipients. Despite the large number of vaccination studies preformed over the past decades, knowledge on vaccination response is still limited. Even though the protection, which can be achieved in SOT recipients through vaccination, appears encouraging on the basis of available data, current vaccination guidelines and recommendations for post-SOT recipients remain poorly supported by evidence. There is an urgent need to conduct appropriately powered vaccination trials in well-defined SOT recipient cohorts.
format	article
author	Isabella Eckerle Kerstin Daniela Rosenberger Marcel Zwahlen Thomas Junghanss
author_facet	Isabella Eckerle Kerstin Daniela Rosenberger Marcel Zwahlen Thomas Junghanss
author_sort	Isabella Eckerle
title	Serologic vaccination response after solid organ transplantation: a systematic review.
title_short	Serologic vaccination response after solid organ transplantation: a systematic review.
title_full	Serologic vaccination response after solid organ transplantation: a systematic review.
title_fullStr	Serologic vaccination response after solid organ transplantation: a systematic review.
title_full_unstemmed	Serologic vaccination response after solid organ transplantation: a systematic review.
title_sort	serologic vaccination response after solid organ transplantation: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5a84fe63223c4aeaa613f3e8dc8e7a0b
work_keys_str_mv	AT isabellaeckerle serologicvaccinationresponseaftersolidorgantransplantationasystematicreview AT kerstindanielarosenberger serologicvaccinationresponseaftersolidorgantransplantationasystematicreview AT marcelzwahlen serologicvaccinationresponseaftersolidorgantransplantationasystematicreview AT thomasjunghanss serologicvaccinationresponseaftersolidorgantransplantationasystematicreview
_version_	1718422731266981888

Serologic vaccination response after solid organ transplantation: a systematic review.

Ejemplares similares