A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children

Abstract There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separa...

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Autores principales:	Pallavi Dubey, Bhaskar Thakur, Sheryl Rodriguez, Jessika Cox, Sheralyn Sanchez, Anacani Fonseca, Sireesha Reddy, Deborah Clegg, Alok Kumar Dwivedi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5a86e0ac984e4fbcaa38a7076c24edc4
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spelling	oai:doaj.org-article:5a86e0ac984e4fbcaa38a7076c24edc42021-11-14T12:11:21ZA systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children10.1038/s41398-021-01699-82158-3188https://doaj.org/article/5a86e0ac984e4fbcaa38a7076c24edc42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01699-8https://doaj.org/toc/2158-3188Abstract There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separately for males and females has not been examined. We sought to systematically evaluate the influence of maternal PCOS on a wide range of NPD including ASD, attention deficit hyperactivity disorder (ADHD), chronic tic disorder (CDT), other behavior disorders, anxiety, depression, bipolar disorder, schizophrenia in children as well as in women of reproductive age only. We queried electronic databases including PubMed, EMBASE, and Google Scholar, until March 2021. We used DerSimonian and Laird (D-L) random effects method to compute pooled effect size in terms of odds ratio (OR). Nineteen studies (1667851 mothers, 2260622 children) were included in this study. Mothers with PCOS had an increased odds of children diagnosed with ASD (OR = 1.40, p < 0.001), ADHD (OR = 1.42, p < 0.001), CTD (OR = 1.44, p = 0.001), anxiety (OR = 1.33, p < 0.001), as well as other behavioral symptoms (OR = 1.45, p < 0.001) in the adjusted analysis. The association between maternal PCOS and ASD (OR: 1.43 vs. 1.66), ADHD (OR: 1.39 vs. 1.54), and CTD (OR: 1.42 vs. 1.51) was found to be significantly consistent between males and females, respectively. Our data do not suggest increased fetal testosterone exposure is associated with increased autistic traits in children. However, PCOS was significantly associated with increased odds of a wide range of NPD in women themselves. Maternal PCOS is a risk factor for various NPD with a similar extent in their children regardless of their underlying comorbidities. Managing PCOS is essential for women’s health as well as for their children’s health. More research is needed to determine the mechanisms and links between maternal PCOS and NPD in children.Pallavi DubeyBhaskar ThakurSheryl RodriguezJessika CoxSheralyn SanchezAnacani FonsecaSireesha ReddyDeborah CleggAlok Kumar DwivediNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Pallavi Dubey Bhaskar Thakur Sheryl Rodriguez Jessika Cox Sheralyn Sanchez Anacani Fonseca Sireesha Reddy Deborah Clegg Alok Kumar Dwivedi A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
description	Abstract There is emerging evidence demonstrating an association between maternal polycystic ovary syndrome (PCOS) and autism spectrum disorder (ASD) in children, however, the cumulative effect of maternal PCOS on the development of ASD or other neuropsychiatry disorders (NPD) in children and separately for males and females has not been examined. We sought to systematically evaluate the influence of maternal PCOS on a wide range of NPD including ASD, attention deficit hyperactivity disorder (ADHD), chronic tic disorder (CDT), other behavior disorders, anxiety, depression, bipolar disorder, schizophrenia in children as well as in women of reproductive age only. We queried electronic databases including PubMed, EMBASE, and Google Scholar, until March 2021. We used DerSimonian and Laird (D-L) random effects method to compute pooled effect size in terms of odds ratio (OR). Nineteen studies (1667851 mothers, 2260622 children) were included in this study. Mothers with PCOS had an increased odds of children diagnosed with ASD (OR = 1.40, p < 0.001), ADHD (OR = 1.42, p < 0.001), CTD (OR = 1.44, p = 0.001), anxiety (OR = 1.33, p < 0.001), as well as other behavioral symptoms (OR = 1.45, p < 0.001) in the adjusted analysis. The association between maternal PCOS and ASD (OR: 1.43 vs. 1.66), ADHD (OR: 1.39 vs. 1.54), and CTD (OR: 1.42 vs. 1.51) was found to be significantly consistent between males and females, respectively. Our data do not suggest increased fetal testosterone exposure is associated with increased autistic traits in children. However, PCOS was significantly associated with increased odds of a wide range of NPD in women themselves. Maternal PCOS is a risk factor for various NPD with a similar extent in their children regardless of their underlying comorbidities. Managing PCOS is essential for women’s health as well as for their children’s health. More research is needed to determine the mechanisms and links between maternal PCOS and NPD in children.
format	article
author	Pallavi Dubey Bhaskar Thakur Sheryl Rodriguez Jessika Cox Sheralyn Sanchez Anacani Fonseca Sireesha Reddy Deborah Clegg Alok Kumar Dwivedi
author_facet	Pallavi Dubey Bhaskar Thakur Sheryl Rodriguez Jessika Cox Sheralyn Sanchez Anacani Fonseca Sireesha Reddy Deborah Clegg Alok Kumar Dwivedi
author_sort	Pallavi Dubey
title	A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
title_short	A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
title_full	A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
title_fullStr	A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
title_full_unstemmed	A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
title_sort	systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/5a86e0ac984e4fbcaa38a7076c24edc4
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A systematic review and meta-analysis of the association between maternal polycystic ovary syndrome and neuropsychiatric disorders in children

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