Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition

The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solut...

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Autores principales:	Pooja Kumari, Florian Aeschimann, Dimos Gaidatzis, Jeremy J. Keusch, Pritha Ghosh, Anca Neagu, Katarzyna Pachulska-Wieczorek, Janusz M. Bujnicki, Heinz Gut, Helge Großhans, Rafal Ciosk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a8959f36aff458cb62b172ede6df265
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spelling	oai:doaj.org-article:5a8959f36aff458cb62b172ede6df2652021-12-02T15:34:46ZEvolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition10.1038/s41467-018-03920-72041-1723https://doaj.org/article/5a8959f36aff458cb62b172ede6df2652018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03920-7https://doaj.org/toc/2041-1723The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solutions to RNA recognition.Pooja KumariFlorian AeschimannDimos GaidatzisJeremy J. KeuschPritha GhoshAnca NeaguKatarzyna Pachulska-WieczorekJanusz M. BujnickiHeinz GutHelge GroßhansRafal CioskNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pooja Kumari Florian Aeschimann Dimos Gaidatzis Jeremy J. Keusch Pritha Ghosh Anca Neagu Katarzyna Pachulska-Wieczorek Janusz M. Bujnicki Heinz Gut Helge Großhans Rafal Ciosk Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
description	The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solutions to RNA recognition.
format	article
author	Pooja Kumari Florian Aeschimann Dimos Gaidatzis Jeremy J. Keusch Pritha Ghosh Anca Neagu Katarzyna Pachulska-Wieczorek Janusz M. Bujnicki Heinz Gut Helge Großhans Rafal Ciosk
author_facet	Pooja Kumari Florian Aeschimann Dimos Gaidatzis Jeremy J. Keusch Pritha Ghosh Anca Neagu Katarzyna Pachulska-Wieczorek Janusz M. Bujnicki Heinz Gut Helge Großhans Rafal Ciosk
author_sort	Pooja Kumari
title	Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
title_short	Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
title_full	Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
title_fullStr	Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
title_full_unstemmed	Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
title_sort	evolutionary plasticity of the nhl domain underlies distinct solutions to rna recognition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5a8959f36aff458cb62b172ede6df265
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Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition

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