A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping o...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2009
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5a980483294048fb98aef6917b624695 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5a980483294048fb98aef6917b624695 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5a980483294048fb98aef6917b6246952021-11-25T05:41:45ZA proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.1553-734X1553-735810.1371/journal.pcbi.1000334https://doaj.org/article/5a980483294048fb98aef6917b6246952009-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19325892/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.Jason W BohlandCaizhi WuHelen BarbasHemant BokilMihail BotaHans C BreiterHollis T ClineJohn C DoylePeter J FreedRalph J GreenspanSuzanne N HaberMichael HawrylyczDaniel G HerreraClaus C HilgetagZ Josh HuangAllan JonesEdward G JonesHarvey J KartenDavid KleinfeldRolf KötterHenry A LesterJohn M LinBrett D MenshShawn MikulaJaak PankseppJoseph L PriceJoseph SafdiehClifford B SaperNicholas D SchiffJeremy D SchmahmannBruce W StillmanKarel SvobodaLarry W SwansonArthur W TogaDavid C Van EssenJames D WatsonPartha P MitraPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 3, p e1000334 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Jason W Bohland Caizhi Wu Helen Barbas Hemant Bokil Mihail Bota Hans C Breiter Hollis T Cline John C Doyle Peter J Freed Ralph J Greenspan Suzanne N Haber Michael Hawrylycz Daniel G Herrera Claus C Hilgetag Z Josh Huang Allan Jones Edward G Jones Harvey J Karten David Kleinfeld Rolf Kötter Henry A Lester John M Lin Brett D Mensh Shawn Mikula Jaak Panksepp Joseph L Price Joseph Safdieh Clifford B Saper Nicholas D Schiff Jeremy D Schmahmann Bruce W Stillman Karel Svoboda Larry W Swanson Arthur W Toga David C Van Essen James D Watson Partha P Mitra A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| description |
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget. |
| format |
article |
| author |
Jason W Bohland Caizhi Wu Helen Barbas Hemant Bokil Mihail Bota Hans C Breiter Hollis T Cline John C Doyle Peter J Freed Ralph J Greenspan Suzanne N Haber Michael Hawrylycz Daniel G Herrera Claus C Hilgetag Z Josh Huang Allan Jones Edward G Jones Harvey J Karten David Kleinfeld Rolf Kötter Henry A Lester John M Lin Brett D Mensh Shawn Mikula Jaak Panksepp Joseph L Price Joseph Safdieh Clifford B Saper Nicholas D Schiff Jeremy D Schmahmann Bruce W Stillman Karel Svoboda Larry W Swanson Arthur W Toga David C Van Essen James D Watson Partha P Mitra |
| author_facet |
Jason W Bohland Caizhi Wu Helen Barbas Hemant Bokil Mihail Bota Hans C Breiter Hollis T Cline John C Doyle Peter J Freed Ralph J Greenspan Suzanne N Haber Michael Hawrylycz Daniel G Herrera Claus C Hilgetag Z Josh Huang Allan Jones Edward G Jones Harvey J Karten David Kleinfeld Rolf Kötter Henry A Lester John M Lin Brett D Mensh Shawn Mikula Jaak Panksepp Joseph L Price Joseph Safdieh Clifford B Saper Nicholas D Schiff Jeremy D Schmahmann Bruce W Stillman Karel Svoboda Larry W Swanson Arthur W Toga David C Van Essen James D Watson Partha P Mitra |
| author_sort |
Jason W Bohland |
| title |
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_short |
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_full |
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_fullStr |
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_full_unstemmed |
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| title_sort |
proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2009 |
| url |
https://doaj.org/article/5a980483294048fb98aef6917b624695 |
| work_keys_str_mv |
AT jasonwbohland aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT caizhiwu aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT helenbarbas aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT hemantbokil aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT mihailbota aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT hanscbreiter aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT hollistcline aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT johncdoyle aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT peterjfreed aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT ralphjgreenspan aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT suzannenhaber aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT michaelhawrylycz aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT danielgherrera aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT clauschilgetag aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT zjoshhuang aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT allanjones aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT edwardgjones aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT harveyjkarten aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT davidkleinfeld aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT rolfkotter aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT henryalester aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT johnmlin aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT brettdmensh aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT shawnmikula aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jaakpanksepp aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT josephlprice aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT josephsafdieh aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT cliffordbsaper aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT nicholasdschiff aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jeremydschmahmann aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT brucewstillman aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT karelsvoboda aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT larrywswanson aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT arthurwtoga aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT davidcvanessen aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jamesdwatson aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT parthapmitra aproposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jasonwbohland proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT caizhiwu proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT helenbarbas proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT hemantbokil proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT mihailbota proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT hanscbreiter proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT hollistcline proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT johncdoyle proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT peterjfreed proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT ralphjgreenspan proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT suzannenhaber proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT michaelhawrylycz proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT danielgherrera proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT clauschilgetag proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT zjoshhuang proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT allanjones proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT edwardgjones proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT harveyjkarten proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT davidkleinfeld proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT rolfkotter proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT henryalester proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT johnmlin proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT brettdmensh proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT shawnmikula proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jaakpanksepp proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT josephlprice proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT josephsafdieh proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT cliffordbsaper proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT nicholasdschiff proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jeremydschmahmann proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT brucewstillman proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT karelsvoboda proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT larrywswanson proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT arthurwtoga proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT davidcvanessen proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT jamesdwatson proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale AT parthapmitra proposalforacoordinatedeffortforthedeterminationofbrainwideneuroanatomicalconnectivityinmodelorganismsatamesoscopicscale |
| _version_ |
1718414518194798592 |