Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

<h4>Background</h4>The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and or...

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Bibliographic Details
Main Authors: Valerie C Henderson, Jonathan Kimmelman, Dean Fergusson, Jeremy M Grimshaw, Dan G Hackam
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Online Access:https://doaj.org/article/5a9da298f96d473892d5be3fc7ee48fe
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