Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages

Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages

Abstract Mycobacterium tuberculosis (Mtb) uses alveolar macrophages as primary host cells during infection. In response to an infection, macrophages switch from pyruvate oxidation to reduction of pyruvate into lactate. Lactate might present an additional carbon substrate for Mtb. Here, we demonstrat...

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Autores principales: Sandra Billig, Marie Schneefeld, Claudia Huber, Guntram A. Grassl, Wolfgang Eisenreich, Franz-Christoph Bange
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/5a9ddd76b9534aa68d725bfbe922215f
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