High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke

Abstract The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). We included consecutiv...

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Autores principales:	Ki-Woong Nam, Hyung-Min Kwon, Yong-Seok Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a9f3317b714402fbf6a3df35576417f
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spelling	oai:doaj.org-article:5a9f3317b714402fbf6a3df35576417f2021-12-02T16:31:02ZHigh triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke10.1038/s41598-021-94631-52045-2322https://doaj.org/article/5a9f3317b714402fbf6a3df35576417f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94631-5https://doaj.org/toc/2045-2322Abstract The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). We included consecutive patients diagnosed with AIS between 2010 and 2016. ERILs were defined as new diffusion-weighted imaging lesions outside the initial symptomatic lesion area. The TyG index was calculated using the following formula: log scale of fasting triglyceride × fasting glucose/2. A total of 176 patients with AIS were evaluated. In the multivariable analysis, the TyG index remained significant (adjusted odds ratio [aOR] 2.63, 95% confidence interval [CI] 1.34–5.15). This close correlation between the TyG index and ERIL was pronounced in ERIL-same group (aOR 2.84, 95% CI 1.40–5.78), but not in ERIL-different group. When comparing the relationship between the TyG index and ERIL by stroke mechanisms, only the intracranial- and extracranial-large artery atherosclerosis groups showed significantly higher TyG index values in patients with ERIL than those without. In conclusion, a higher TyG index was associated with ERIL, especially ERIL-same, in patients with AIS. The TyG index appears to be involved in ERIL occurrence by a mechanism related to atherosclerosis.Ki-Woong NamHyung-Min KwonYong-Seok LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
description	Abstract The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). We included consecutive patients diagnosed with AIS between 2010 and 2016. ERILs were defined as new diffusion-weighted imaging lesions outside the initial symptomatic lesion area. The TyG index was calculated using the following formula: log scale of fasting triglyceride × fasting glucose/2. A total of 176 patients with AIS were evaluated. In the multivariable analysis, the TyG index remained significant (adjusted odds ratio [aOR] 2.63, 95% confidence interval [CI] 1.34–5.15). This close correlation between the TyG index and ERIL was pronounced in ERIL-same group (aOR 2.84, 95% CI 1.40–5.78), but not in ERIL-different group. When comparing the relationship between the TyG index and ERIL by stroke mechanisms, only the intracranial- and extracranial-large artery atherosclerosis groups showed significantly higher TyG index values in patients with ERIL than those without. In conclusion, a higher TyG index was associated with ERIL, especially ERIL-same, in patients with AIS. The TyG index appears to be involved in ERIL occurrence by a mechanism related to atherosclerosis.
format	article
author	Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee
author_facet	Ki-Woong Nam Hyung-Min Kwon Yong-Seok Lee
author_sort	Ki-Woong Nam
title	High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
title_short	High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
title_full	High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
title_fullStr	High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
title_full_unstemmed	High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
title_sort	high triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a9f3317b714402fbf6a3df35576417f
work_keys_str_mv	AT kiwoongnam hightriglycerideglucoseindexisassociatedwithearlyrecurrentischemiclesioninacuteischemicstroke AT hyungminkwon hightriglycerideglucoseindexisassociatedwithearlyrecurrentischemiclesioninacuteischemicstroke AT yongseoklee hightriglycerideglucoseindexisassociatedwithearlyrecurrentischemiclesioninacuteischemicstroke
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High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke

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