Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.

Monoaminergic and neuropeptidergic neurons regulate a wide variety of behaviors, such as feeding, sleep/wakefulness behavior, stress response, addiction, and social behavior. These neurons form neural circuits to integrate different modalities of behavioral and environmental factors, such as stress,...

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Autores principales:	Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5aa9e815f6de4449ace583452c198cba
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spelling	oai:doaj.org-article:5aa9e815f6de4449ace583452c198cba2021-11-18T07:55:05ZMonoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.1932-620310.1371/journal.pone.0058473https://doaj.org/article/5aa9e815f6de4449ace583452c198cba2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23469282/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Monoaminergic and neuropeptidergic neurons regulate a wide variety of behaviors, such as feeding, sleep/wakefulness behavior, stress response, addiction, and social behavior. These neurons form neural circuits to integrate different modalities of behavioral and environmental factors, such as stress, maternal care, and feeding conditions. One possible mechanism for integrating environmental factors through the monoaminergic and neuropeptidergic neurons is through the epigenetic regulation of gene expression via altered acetylation of histones. Histone deacetylases (HDACs) play an important role in altering behavior in response to environmental factors. Despite increasing attention and the versatile roles of HDACs in a variety of brain functions and disorders, no reports have detailed the localization of the HDACs in the monoaminergic and neuropeptidergic neurons. Here, we examined the expression profile of the HDAC protein family from HDAC1 to HDAC11 in corticotropin-releasing hormone, oxytocin, vasopressin, agouti-related peptide (AgRP), pro-opiomelanocortin (POMC), orexin, histamine, dopamine, serotonin, and noradrenaline neurons. Immunoreactivities for HDAC1,-2,-3,-5,-6,-7,-9, and -11 were very similar among the monoaminergic and neuropeptidergic neurons, while the HDAC4, -8, and -10 immunoreactivities were clearly different among neuronal groups. HDAC10 expression was found in AgRP neurons, POMC neurons, dopamine neurons and noradrenaline neurons but not in other neuronal groups. HDAC8 immunoreactivity was detected in the cytoplasm of almost all histamine neurons with a pericellular pattern but not in other neuropeptidergic and monoaminergic neurons. Thus, the differential expression of HDACs in monoaminergic and neuropeptidergic neurons may be crucial for the maintenance of biological characteristics and may be altered in response to environmental factors.Kenkichi TakaseSatoko OdaMasaru KurodaHiromasa FunatoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58473 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenkichi Takase Satoko Oda Masaru Kuroda Hiromasa Funato Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
description	Monoaminergic and neuropeptidergic neurons regulate a wide variety of behaviors, such as feeding, sleep/wakefulness behavior, stress response, addiction, and social behavior. These neurons form neural circuits to integrate different modalities of behavioral and environmental factors, such as stress, maternal care, and feeding conditions. One possible mechanism for integrating environmental factors through the monoaminergic and neuropeptidergic neurons is through the epigenetic regulation of gene expression via altered acetylation of histones. Histone deacetylases (HDACs) play an important role in altering behavior in response to environmental factors. Despite increasing attention and the versatile roles of HDACs in a variety of brain functions and disorders, no reports have detailed the localization of the HDACs in the monoaminergic and neuropeptidergic neurons. Here, we examined the expression profile of the HDAC protein family from HDAC1 to HDAC11 in corticotropin-releasing hormone, oxytocin, vasopressin, agouti-related peptide (AgRP), pro-opiomelanocortin (POMC), orexin, histamine, dopamine, serotonin, and noradrenaline neurons. Immunoreactivities for HDAC1,-2,-3,-5,-6,-7,-9, and -11 were very similar among the monoaminergic and neuropeptidergic neurons, while the HDAC4, -8, and -10 immunoreactivities were clearly different among neuronal groups. HDAC10 expression was found in AgRP neurons, POMC neurons, dopamine neurons and noradrenaline neurons but not in other neuronal groups. HDAC8 immunoreactivity was detected in the cytoplasm of almost all histamine neurons with a pericellular pattern but not in other neuropeptidergic and monoaminergic neurons. Thus, the differential expression of HDACs in monoaminergic and neuropeptidergic neurons may be crucial for the maintenance of biological characteristics and may be altered in response to environmental factors.
format	article
author	Kenkichi Takase Satoko Oda Masaru Kuroda Hiromasa Funato
author_facet	Kenkichi Takase Satoko Oda Masaru Kuroda Hiromasa Funato
author_sort	Kenkichi Takase
title	Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
title_short	Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
title_full	Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
title_fullStr	Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
title_full_unstemmed	Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
title_sort	monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5aa9e815f6de4449ace583452c198cba
work_keys_str_mv	AT kenkichitakase monoaminergicandneuropeptidergicneuronshavedistinctexpressionprofilesofhistonedeacetylases AT satokooda monoaminergicandneuropeptidergicneuronshavedistinctexpressionprofilesofhistonedeacetylases AT masarukuroda monoaminergicandneuropeptidergicneuronshavedistinctexpressionprofilesofhistonedeacetylases AT hiromasafunato monoaminergicandneuropeptidergicneuronshavedistinctexpressionprofilesofhistonedeacetylases
_version_	1718422731703189504

Monoaminergic and neuropeptidergic neurons have distinct expression profiles of histone deacetylases.

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