CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events and discover an effect on conjoined gene transcri...

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Autores principales:	Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
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spelling	oai:doaj.org-article:5aad2179e7e647afa20357dc81dea1bc2021-12-02T10:48:19ZCLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor10.1038/s41467-016-0008-72041-1723https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-016-0008-7https://doaj.org/toc/2041-1723The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events and discover an effect on conjoined gene transcription.Tyler FunnellShinya TasakiArusha OloumiShinsuke ArakiEsther KongDamian YapYusuke NakayamaChristopher S. HughesS.-W. Grace ChengHirokazu TozakiMisa IwataniSatoshi SasakiTomohiro OhashiTohru MiyazakiNao MorishitaDaisuke MorishitaMari Ogasawara-ShimizuMomoko OhoriShoichi NakaoMasatoshi KarashimaMasaya SanoAiko MuraiToshiyuki NomuraNoriko UchiyamaTomohiro KawamotoRyujiro HaraOsamu NakanishiKarey ShumanskyJamie RosnerAdrian WanSteven McKinneyGregg B. MorinAtsushi NakanishiSohrab ShahHiroyoshi ToyoshibaSamuel AparicioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tyler Funnell Shinya Tasaki Arusha Oloumi Shinsuke Araki Esther Kong Damian Yap Yusuke Nakayama Christopher S. Hughes S.-W. Grace Cheng Hirokazu Tozaki Misa Iwatani Satoshi Sasaki Tomohiro Ohashi Tohru Miyazaki Nao Morishita Daisuke Morishita Mari Ogasawara-Shimizu Momoko Ohori Shoichi Nakao Masatoshi Karashima Masaya Sano Aiko Murai Toshiyuki Nomura Noriko Uchiyama Tomohiro Kawamoto Ryujiro Hara Osamu Nakanishi Karey Shumansky Jamie Rosner Adrian Wan Steven McKinney Gregg B. Morin Atsushi Nakanishi Sohrab Shah Hiroyoshi Toyoshiba Samuel Aparicio CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
description	The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events and discover an effect on conjoined gene transcription.
format	article
author	Tyler Funnell Shinya Tasaki Arusha Oloumi Shinsuke Araki Esther Kong Damian Yap Yusuke Nakayama Christopher S. Hughes S.-W. Grace Cheng Hirokazu Tozaki Misa Iwatani Satoshi Sasaki Tomohiro Ohashi Tohru Miyazaki Nao Morishita Daisuke Morishita Mari Ogasawara-Shimizu Momoko Ohori Shoichi Nakao Masatoshi Karashima Masaya Sano Aiko Murai Toshiyuki Nomura Noriko Uchiyama Tomohiro Kawamoto Ryujiro Hara Osamu Nakanishi Karey Shumansky Jamie Rosner Adrian Wan Steven McKinney Gregg B. Morin Atsushi Nakanishi Sohrab Shah Hiroyoshi Toyoshiba Samuel Aparicio
author_facet	Tyler Funnell Shinya Tasaki Arusha Oloumi Shinsuke Araki Esther Kong Damian Yap Yusuke Nakayama Christopher S. Hughes S.-W. Grace Cheng Hirokazu Tozaki Misa Iwatani Satoshi Sasaki Tomohiro Ohashi Tohru Miyazaki Nao Morishita Daisuke Morishita Mari Ogasawara-Shimizu Momoko Ohori Shoichi Nakao Masatoshi Karashima Masaya Sano Aiko Murai Toshiyuki Nomura Noriko Uchiyama Tomohiro Kawamoto Ryujiro Hara Osamu Nakanishi Karey Shumansky Jamie Rosner Adrian Wan Steven McKinney Gregg B. Morin Atsushi Nakanishi Sohrab Shah Hiroyoshi Toyoshiba Samuel Aparicio
author_sort	Tyler Funnell
title	CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
title_short	CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
title_full	CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
title_fullStr	CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
title_full_unstemmed	CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
title_sort	clk-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
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CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

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