Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice

The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a m...

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Autores principales:	Elaine Soares, Aruanna C. Soares, Patricia Leticia Trindade, Elisa B. Monteiro, Fabiane F. Martins, Andrew J. Forgie, Kim O.P. Inada, Graziele F. de Bem, Angela Resende, Daniel Perrone, Vanessa Souza-Mello, Francisco Tomás-Barberán, Benjamin P. Willing, Mariana Monteiro, Julio B. Daleprane
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Obesity Polyphenols Steatosis Nutrigenomics Metabolism Gut microbiota Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5ab00f7fd3eb467e800e5dd1438d8be5
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spelling	oai:doaj.org-article:5ab00f7fd3eb467e800e5dd1438d8be52021-11-14T04:29:34ZJaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice0753-332210.1016/j.biopha.2021.112314https://doaj.org/article/5ab00f7fd3eb467e800e5dd1438d8be52021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010982https://doaj.org/toc/0753-3322The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a mouse model of NAFLD. Three-month-old C57BL/6 J male mice, received either a control (C, 10% of lipids as energy, n = 16) or high-fat (HF, 50% of lipids as energy, n = 64) diet for nine weeks. The HF mice were randomly subdivided into four groups (n = 16 in each group), three of which (HF-J5, HF-J10, and HF-J15) were supplemented with dietary JPSP for four weeks (5%, 10%, and 15%, respectively). In addition to attenuating weight gain, JPSP consumption improved dyslipidemia and insulin resistance. In a dose-dependent manner, JPSP consumption ameliorated the expression of hepatic lipogenesis genes (AMPK, SREBP-1, HGMCoA, and ABCG8). The effects on the microbial community structure were determined in all JPSP-supplemented groups; however, the HF-J10 and HF-J15 diets led to a drastic depletion in the species of numerous bacterial families (Bifidobacteriaceae, Mogibacteriaceae, Christensenellaceae, Clostridiaceae, Dehalobacteriaceae, Peptococcaceae, Peptostreptococcaceae, and Ruminococcaceae) compared to the HF diet, some of which represented a reversal of increases associated with HF. The Lachnospiraceae and Enterobacteriaceae families and the Parabacteroides, Sutterella, Allobaculum, and Akkermansia genera were enriched more in the HF-J10 and HF-J15 groups than in the HF group. In conclusion, JPSP consumption improved obesity-related metabolic profiles and had a strong impact on the microbial community structure, thereby reversing NAFLD and decreasing its severity.Elaine SoaresAruanna C. SoaresPatricia Leticia TrindadeElisa B. MonteiroFabiane F. MartinsAndrew J. ForgieKim O.P. InadaGraziele F. de BemAngela ResendeDaniel PerroneVanessa Souza-MelloFrancisco Tomás-BarberánBenjamin P. WillingMariana MonteiroJulio B. DalepraneElsevierarticleObesityPolyphenolsSteatosisNutrigenomicsMetabolismGut microbiotaTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112314- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity Polyphenols Steatosis Nutrigenomics Metabolism Gut microbiota Therapeutics. Pharmacology RM1-950
spellingShingle	Obesity Polyphenols Steatosis Nutrigenomics Metabolism Gut microbiota Therapeutics. Pharmacology RM1-950 Elaine Soares Aruanna C. Soares Patricia Leticia Trindade Elisa B. Monteiro Fabiane F. Martins Andrew J. Forgie Kim O.P. Inada Graziele F. de Bem Angela Resende Daniel Perrone Vanessa Souza-Mello Francisco Tomás-Barberán Benjamin P. Willing Mariana Monteiro Julio B. Daleprane Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
description	The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis and non-alcoholic fatty liver disease (NAFLD). We evaluated the effect of polyphenol-rich jaboticaba peel and seed powder (JPSP) on the gut microbial community composition and liver health in a mouse model of NAFLD. Three-month-old C57BL/6 J male mice, received either a control (C, 10% of lipids as energy, n = 16) or high-fat (HF, 50% of lipids as energy, n = 64) diet for nine weeks. The HF mice were randomly subdivided into four groups (n = 16 in each group), three of which (HF-J5, HF-J10, and HF-J15) were supplemented with dietary JPSP for four weeks (5%, 10%, and 15%, respectively). In addition to attenuating weight gain, JPSP consumption improved dyslipidemia and insulin resistance. In a dose-dependent manner, JPSP consumption ameliorated the expression of hepatic lipogenesis genes (AMPK, SREBP-1, HGMCoA, and ABCG8). The effects on the microbial community structure were determined in all JPSP-supplemented groups; however, the HF-J10 and HF-J15 diets led to a drastic depletion in the species of numerous bacterial families (Bifidobacteriaceae, Mogibacteriaceae, Christensenellaceae, Clostridiaceae, Dehalobacteriaceae, Peptococcaceae, Peptostreptococcaceae, and Ruminococcaceae) compared to the HF diet, some of which represented a reversal of increases associated with HF. The Lachnospiraceae and Enterobacteriaceae families and the Parabacteroides, Sutterella, Allobaculum, and Akkermansia genera were enriched more in the HF-J10 and HF-J15 groups than in the HF group. In conclusion, JPSP consumption improved obesity-related metabolic profiles and had a strong impact on the microbial community structure, thereby reversing NAFLD and decreasing its severity.
format	article
author	Elaine Soares Aruanna C. Soares Patricia Leticia Trindade Elisa B. Monteiro Fabiane F. Martins Andrew J. Forgie Kim O.P. Inada Graziele F. de Bem Angela Resende Daniel Perrone Vanessa Souza-Mello Francisco Tomás-Barberán Benjamin P. Willing Mariana Monteiro Julio B. Daleprane
author_facet	Elaine Soares Aruanna C. Soares Patricia Leticia Trindade Elisa B. Monteiro Fabiane F. Martins Andrew J. Forgie Kim O.P. Inada Graziele F. de Bem Angela Resende Daniel Perrone Vanessa Souza-Mello Francisco Tomás-Barberán Benjamin P. Willing Mariana Monteiro Julio B. Daleprane
author_sort	Elaine Soares
title	Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
title_short	Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
title_full	Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
title_fullStr	Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
title_full_unstemmed	Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
title_sort	jaboticaba (myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5ab00f7fd3eb467e800e5dd1438d8be5
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Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice

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