Quantifying CDK inhibitor selectivity in live cells
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhib...
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Nature Portfolio
2020
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oai:doaj.org-article:5ab2cf72cb7f4b5ea0a65e02f4e02daf2021-12-02T18:24:49ZQuantifying CDK inhibitor selectivity in live cells10.1038/s41467-020-16559-02041-1723https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16559-0https://doaj.org/toc/2041-1723Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells.Carrow I. WellsJames D. VastaCesear R. CoronaJennifer WilkinsonChad A. ZimprichMorgan R. IngoldJulie E. PickettDavid H. DrewryKathryn M. PughMarie K. SchwinnByounghoon (Brian) HwangHicham ZegzoutiKilian V. M. HuberMei CongPoncho L. MeisenheimerTimothy M. WillsonMatthew B. RobersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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Science Q Carrow I. Wells James D. Vasta Cesear R. Corona Jennifer Wilkinson Chad A. Zimprich Morgan R. Ingold Julie E. Pickett David H. Drewry Kathryn M. Pugh Marie K. Schwinn Byounghoon (Brian) Hwang Hicham Zegzouti Kilian V. M. Huber Mei Cong Poncho L. Meisenheimer Timothy M. Willson Matthew B. Robers Quantifying CDK inhibitor selectivity in live cells |
description |
Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells. |
format |
article |
author |
Carrow I. Wells James D. Vasta Cesear R. Corona Jennifer Wilkinson Chad A. Zimprich Morgan R. Ingold Julie E. Pickett David H. Drewry Kathryn M. Pugh Marie K. Schwinn Byounghoon (Brian) Hwang Hicham Zegzouti Kilian V. M. Huber Mei Cong Poncho L. Meisenheimer Timothy M. Willson Matthew B. Robers |
author_facet |
Carrow I. Wells James D. Vasta Cesear R. Corona Jennifer Wilkinson Chad A. Zimprich Morgan R. Ingold Julie E. Pickett David H. Drewry Kathryn M. Pugh Marie K. Schwinn Byounghoon (Brian) Hwang Hicham Zegzouti Kilian V. M. Huber Mei Cong Poncho L. Meisenheimer Timothy M. Willson Matthew B. Robers |
author_sort |
Carrow I. Wells |
title |
Quantifying CDK inhibitor selectivity in live cells |
title_short |
Quantifying CDK inhibitor selectivity in live cells |
title_full |
Quantifying CDK inhibitor selectivity in live cells |
title_fullStr |
Quantifying CDK inhibitor selectivity in live cells |
title_full_unstemmed |
Quantifying CDK inhibitor selectivity in live cells |
title_sort |
quantifying cdk inhibitor selectivity in live cells |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf |
work_keys_str_mv |
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