Quantifying CDK inhibitor selectivity in live cells

Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhib...

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Autores principales: Carrow I. Wells, James D. Vasta, Cesear R. Corona, Jennifer Wilkinson, Chad A. Zimprich, Morgan R. Ingold, Julie E. Pickett, David H. Drewry, Kathryn M. Pugh, Marie K. Schwinn, Byounghoon (Brian) Hwang, Hicham Zegzouti, Kilian V. M. Huber, Mei Cong, Poncho L. Meisenheimer, Timothy M. Willson, Matthew B. Robers
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf
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spelling oai:doaj.org-article:5ab2cf72cb7f4b5ea0a65e02f4e02daf2021-12-02T18:24:49ZQuantifying CDK inhibitor selectivity in live cells10.1038/s41467-020-16559-02041-1723https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16559-0https://doaj.org/toc/2041-1723Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells.Carrow I. WellsJames D. VastaCesear R. CoronaJennifer WilkinsonChad A. ZimprichMorgan R. IngoldJulie E. PickettDavid H. DrewryKathryn M. PughMarie K. SchwinnByounghoon (Brian) HwangHicham ZegzoutiKilian V. M. HuberMei CongPoncho L. MeisenheimerTimothy M. WillsonMatthew B. RobersNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Carrow I. Wells
James D. Vasta
Cesear R. Corona
Jennifer Wilkinson
Chad A. Zimprich
Morgan R. Ingold
Julie E. Pickett
David H. Drewry
Kathryn M. Pugh
Marie K. Schwinn
Byounghoon (Brian) Hwang
Hicham Zegzouti
Kilian V. M. Huber
Mei Cong
Poncho L. Meisenheimer
Timothy M. Willson
Matthew B. Robers
Quantifying CDK inhibitor selectivity in live cells
description Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells.
format article
author Carrow I. Wells
James D. Vasta
Cesear R. Corona
Jennifer Wilkinson
Chad A. Zimprich
Morgan R. Ingold
Julie E. Pickett
David H. Drewry
Kathryn M. Pugh
Marie K. Schwinn
Byounghoon (Brian) Hwang
Hicham Zegzouti
Kilian V. M. Huber
Mei Cong
Poncho L. Meisenheimer
Timothy M. Willson
Matthew B. Robers
author_facet Carrow I. Wells
James D. Vasta
Cesear R. Corona
Jennifer Wilkinson
Chad A. Zimprich
Morgan R. Ingold
Julie E. Pickett
David H. Drewry
Kathryn M. Pugh
Marie K. Schwinn
Byounghoon (Brian) Hwang
Hicham Zegzouti
Kilian V. M. Huber
Mei Cong
Poncho L. Meisenheimer
Timothy M. Willson
Matthew B. Robers
author_sort Carrow I. Wells
title Quantifying CDK inhibitor selectivity in live cells
title_short Quantifying CDK inhibitor selectivity in live cells
title_full Quantifying CDK inhibitor selectivity in live cells
title_fullStr Quantifying CDK inhibitor selectivity in live cells
title_full_unstemmed Quantifying CDK inhibitor selectivity in live cells
title_sort quantifying cdk inhibitor selectivity in live cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/5ab2cf72cb7f4b5ea0a65e02f4e02daf
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