The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance
The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance.
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2016
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oai:doaj.org-article:5ab7094df7b24c7e834e933314f7ba852021-12-02T17:32:21ZThe necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance10.1038/ncomms118692041-1723https://doaj.org/article/5ab7094df7b24c7e834e933314f7ba852016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11869https://doaj.org/toc/2041-1723The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance.Jérémie GautheronMihael VucurAnne T. SchneiderIlenia SeveriChristoph RoderburgSanchari RoyMatthias BartneckPeter SchrammenMauricio Berriel DiazJosef EhlingFelix GremseFelix HeymannChristiane KoppeTwan LammersFabian KiesslingNiels Van BestOliver PabstGilles CourtoisAndreas LinkermannStefan KrautwaldUlf P. NeumannFrank TackeChristian TrautweinDouglas R. GreenThomas LongerichNorbert FreyMark LueddeMatthias BluherStephan HerzigMathias HeikenwalderTom LueddeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
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Science Q Jérémie Gautheron Mihael Vucur Anne T. Schneider Ilenia Severi Christoph Roderburg Sanchari Roy Matthias Bartneck Peter Schrammen Mauricio Berriel Diaz Josef Ehling Felix Gremse Felix Heymann Christiane Koppe Twan Lammers Fabian Kiessling Niels Van Best Oliver Pabst Gilles Courtois Andreas Linkermann Stefan Krautwald Ulf P. Neumann Frank Tacke Christian Trautwein Douglas R. Green Thomas Longerich Norbert Frey Mark Luedde Matthias Bluher Stephan Herzig Mathias Heikenwalder Tom Luedde The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance |
| description |
The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance. |
| format |
article |
| author |
Jérémie Gautheron Mihael Vucur Anne T. Schneider Ilenia Severi Christoph Roderburg Sanchari Roy Matthias Bartneck Peter Schrammen Mauricio Berriel Diaz Josef Ehling Felix Gremse Felix Heymann Christiane Koppe Twan Lammers Fabian Kiessling Niels Van Best Oliver Pabst Gilles Courtois Andreas Linkermann Stefan Krautwald Ulf P. Neumann Frank Tacke Christian Trautwein Douglas R. Green Thomas Longerich Norbert Frey Mark Luedde Matthias Bluher Stephan Herzig Mathias Heikenwalder Tom Luedde |
| author_facet |
Jérémie Gautheron Mihael Vucur Anne T. Schneider Ilenia Severi Christoph Roderburg Sanchari Roy Matthias Bartneck Peter Schrammen Mauricio Berriel Diaz Josef Ehling Felix Gremse Felix Heymann Christiane Koppe Twan Lammers Fabian Kiessling Niels Van Best Oliver Pabst Gilles Courtois Andreas Linkermann Stefan Krautwald Ulf P. Neumann Frank Tacke Christian Trautwein Douglas R. Green Thomas Longerich Norbert Frey Mark Luedde Matthias Bluher Stephan Herzig Mathias Heikenwalder Tom Luedde |
| author_sort |
Jérémie Gautheron |
| title |
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance |
| title_short |
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance |
| title_full |
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance |
| title_fullStr |
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance |
| title_full_unstemmed |
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance |
| title_sort |
necroptosis-inducing kinase ripk3 dampens adipose tissue inflammation and glucose intolerance |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/5ab7094df7b24c7e834e933314f7ba85 |
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