Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.

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Bibliographic Details
Main Authors:	Ingrid Poernbacher, Jean-Paul Vincent
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec1
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id	oai:doaj.org-article:5ab7ef674b5e44acbdeb490c8e278ec1
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spelling	oai:doaj.org-article:5ab7ef674b5e44acbdeb490c8e278ec12021-12-02T16:56:55ZEpithelial cells release adenosine to promote local TNF production in response to polarity disruption10.1038/s41467-018-07114-z2041-1723https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec12018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07114-zhttps://doaj.org/toc/2041-1723Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.Ingrid PoernbacherJean-Paul VincentNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ingrid Poernbacher Jean-Paul Vincent Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
description	Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.
format	article
author	Ingrid Poernbacher Jean-Paul Vincent
author_facet	Ingrid Poernbacher Jean-Paul Vincent
author_sort	Ingrid Poernbacher
title	Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_short	Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_full	Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_fullStr	Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_full_unstemmed	Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_sort	epithelial cells release adenosine to promote local tnf production in response to polarity disruption
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec1
work_keys_str_mv	AT ingridpoernbacher epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption AT jeanpaulvincent epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption
_version_	1718382681790611456

Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

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