Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.
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Nature Portfolio
2018
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oai:doaj.org-article:5ab7ef674b5e44acbdeb490c8e278ec12021-12-02T16:56:55ZEpithelial cells release adenosine to promote local TNF production in response to polarity disruption10.1038/s41467-018-07114-z2041-1723https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec12018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07114-zhttps://doaj.org/toc/2041-1723Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.Ingrid PoernbacherJean-Paul VincentNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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Science Q Ingrid Poernbacher Jean-Paul Vincent Epithelial cells release adenosine to promote local TNF production in response to polarity disruption |
description |
Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress. |
format |
article |
author |
Ingrid Poernbacher Jean-Paul Vincent |
author_facet |
Ingrid Poernbacher Jean-Paul Vincent |
author_sort |
Ingrid Poernbacher |
title |
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption |
title_short |
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption |
title_full |
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption |
title_fullStr |
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption |
title_full_unstemmed |
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption |
title_sort |
epithelial cells release adenosine to promote local tnf production in response to polarity disruption |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec1 |
work_keys_str_mv |
AT ingridpoernbacher epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption AT jeanpaulvincent epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption |
_version_ |
1718382681790611456 |