Epithelial cells release adenosine to promote local TNF production in response to polarity disruption

Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.

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Autores principales: Ingrid Poernbacher, Jean-Paul Vincent
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec1
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spelling oai:doaj.org-article:5ab7ef674b5e44acbdeb490c8e278ec12021-12-02T16:56:55ZEpithelial cells release adenosine to promote local TNF production in response to polarity disruption10.1038/s41467-018-07114-z2041-1723https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec12018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07114-zhttps://doaj.org/toc/2041-1723Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.Ingrid PoernbacherJean-Paul VincentNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ingrid Poernbacher
Jean-Paul Vincent
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
description Epithelial stress can disrupt polarity and activate TNF and JNK signalling that contributes to inflammation and cell damage. Here, the authors show that disruption of apico-basal polarity leads to adenosine release, activating TNF and JNK and driving an inflammatory response during chronic stress.
format article
author Ingrid Poernbacher
Jean-Paul Vincent
author_facet Ingrid Poernbacher
Jean-Paul Vincent
author_sort Ingrid Poernbacher
title Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_short Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_full Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_fullStr Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_full_unstemmed Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
title_sort epithelial cells release adenosine to promote local tnf production in response to polarity disruption
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5ab7ef674b5e44acbdeb490c8e278ec1
work_keys_str_mv AT ingridpoernbacher epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption
AT jeanpaulvincent epithelialcellsreleaseadenosinetopromotelocaltnfproductioninresponsetopolaritydisruption
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