SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter...

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Autores principales:	Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha, Haiyong Peng, Brian D. Quinlan, Erumbi S. Rangarajan, Andi Pan, Abigail Vanderheiden, Mehul S. Suthar, Wenhui Li, Tina Izard, Christoph Rader, Michael Farzan, Hyeryun Choe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ab81391dfd1486295e3c90c83762edb
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spelling	oai:doaj.org-article:5ab81391dfd1486295e3c90c83762edb2021-12-02T14:42:15ZSARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity10.1038/s41467-020-19808-42041-1723https://doaj.org/article/5ab81391dfd1486295e3c90c83762edb2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19808-4https://doaj.org/toc/2041-1723SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter cells more efficiently than those carrying S-D614.Lizhou ZhangCody B. JacksonHuihui MouAmrita OjhaHaiyong PengBrian D. QuinlanErumbi S. RangarajanAndi PanAbigail VanderheidenMehul S. SutharWenhui LiTina IzardChristoph RaderMichael FarzanHyeryun ChoeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lizhou Zhang Cody B. Jackson Huihui Mou Amrita Ojha Haiyong Peng Brian D. Quinlan Erumbi S. Rangarajan Andi Pan Abigail Vanderheiden Mehul S. Suthar Wenhui Li Tina Izard Christoph Rader Michael Farzan Hyeryun Choe SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
description	SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614 incorporate higher amounts of S protein and enter cells more efficiently than those carrying S-D614.
format	article
author	Lizhou Zhang Cody B. Jackson Huihui Mou Amrita Ojha Haiyong Peng Brian D. Quinlan Erumbi S. Rangarajan Andi Pan Abigail Vanderheiden Mehul S. Suthar Wenhui Li Tina Izard Christoph Rader Michael Farzan Hyeryun Choe
author_facet	Lizhou Zhang Cody B. Jackson Huihui Mou Amrita Ojha Haiyong Peng Brian D. Quinlan Erumbi S. Rangarajan Andi Pan Abigail Vanderheiden Mehul S. Suthar Wenhui Li Tina Izard Christoph Rader Michael Farzan Hyeryun Choe
author_sort	Lizhou Zhang
title	SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
title_short	SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
title_full	SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
title_fullStr	SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
title_full_unstemmed	SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
title_sort	sars-cov-2 spike-protein d614g mutation increases virion spike density and infectivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5ab81391dfd1486295e3c90c83762edb
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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

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