LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic pancreatic tumors in liver.

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Bibliographic Details
Main Authors: Angélina Acier, Magali Godard, Fanny Gassiot, Pascal Finetti, Marion Rubis, Jonathan Nowak, François Bertucci, Juan L. Iovanna, Richard Tomasini, Pascaline Lécorché, Guillaume Jacquot, Michel Khrestchatisky, Jamal Temsamani, Cédric Malicet, Sophie Vasseur, Fabienne Guillaumond
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/5ab9785210c145ccb6dcb8b2d12b4fdb
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Summary:Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic pancreatic tumors in liver.

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