LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma
Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic pancreatic tumors in liver.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5ab9785210c145ccb6dcb8b2d12b4fdb |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5ab9785210c145ccb6dcb8b2d12b4fdb |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5ab9785210c145ccb6dcb8b2d12b4fdb2021-12-02T15:10:45ZLDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma10.1038/s42003-021-02508-02399-3642https://doaj.org/article/5ab9785210c145ccb6dcb8b2d12b4fdb2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02508-0https://doaj.org/toc/2399-3642Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic pancreatic tumors in liver.Angélina AcierMagali GodardFanny GassiotPascal FinettiMarion RubisJonathan NowakFrançois BertucciJuan L. IovannaRichard TomasiniPascaline LécorchéGuillaume JacquotMichel KhrestchatiskyJamal TemsamaniCédric MalicetSophie VasseurFabienne GuillaumondNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Angélina Acier Magali Godard Fanny Gassiot Pascal Finetti Marion Rubis Jonathan Nowak François Bertucci Juan L. Iovanna Richard Tomasini Pascaline Lécorché Guillaume Jacquot Michel Khrestchatisky Jamal Temsamani Cédric Malicet Sophie Vasseur Fabienne Guillaumond LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| description |
Acier et al. investigated a peptide cargo system, the Fc(A680)-VH4127, that targets PDAC through the LDLR cell-surface receptor. The Fc(A680)-VH4127 was found to specifically target spontaneous pancreatic tumors in KICmice, as well as metastatic pancreatic tumors in liver. |
| format |
article |
| author |
Angélina Acier Magali Godard Fanny Gassiot Pascal Finetti Marion Rubis Jonathan Nowak François Bertucci Juan L. Iovanna Richard Tomasini Pascaline Lécorché Guillaume Jacquot Michel Khrestchatisky Jamal Temsamani Cédric Malicet Sophie Vasseur Fabienne Guillaumond |
| author_facet |
Angélina Acier Magali Godard Fanny Gassiot Pascal Finetti Marion Rubis Jonathan Nowak François Bertucci Juan L. Iovanna Richard Tomasini Pascaline Lécorché Guillaume Jacquot Michel Khrestchatisky Jamal Temsamani Cédric Malicet Sophie Vasseur Fabienne Guillaumond |
| author_sort |
Angélina Acier |
| title |
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| title_short |
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| title_full |
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| title_fullStr |
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| title_full_unstemmed |
LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| title_sort |
ldl receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5ab9785210c145ccb6dcb8b2d12b4fdb |
| work_keys_str_mv |
AT angelinaacier ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT magaligodard ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT fannygassiot ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT pascalfinetti ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT marionrubis ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT jonathannowak ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT francoisbertucci ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT juanliovanna ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT richardtomasini ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT pascalinelecorche ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT guillaumejacquot ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT michelkhrestchatisky ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT jamaltemsamani ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT cedricmalicet ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT sophievasseur ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma AT fabienneguillaumond ldlreceptorpeptideconjugateasinvivotoolforspecifictargetingofpancreaticductaladenocarcinoma |
| _version_ |
1718387690369449984 |