Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis

Jun-Hao Shih,1,2,* Bing-Yan Zeng,3,* Pao-Yen Lin,4,5 Tien-Yu Chen,6,7 Yen-Wen Chen,8 Ching-Kuan Wu,9 Ping-Tao Tseng,10 Ming-Kung Wu4 1Department of Occupational and Environmental Health Consultation, EMHA Consulting International Incorporation, Hsinchu, Taiwan; 2Certified Occupational Medicine Phys...

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Autores principales:	Shih JH, Zeng BY, Lin PY, Chen TY, Chen YW, Wu CK, Tseng PT, Wu MK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	meta-analysis manganese ADHD pediatric psychiatry review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5aba34a03c1442acae807157c2273002
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spelling	oai:doaj.org-article:5aba34a03c1442acae807157c22730022021-12-02T05:16:27ZAssociation between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis1178-2021https://doaj.org/article/5aba34a03c1442acae807157c22730022018-07-01T00:00:00Zhttps://www.dovepress.com/association-between-peripheral-manganese-levels-and-attention-deficith-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jun-Hao Shih,1,2,* Bing-Yan Zeng,3,* Pao-Yen Lin,4,5 Tien-Yu Chen,6,7 Yen-Wen Chen,8 Ching-Kuan Wu,9 Ping-Tao Tseng,10 Ming-Kung Wu4 1Department of Occupational and Environmental Health Consultation, EMHA Consulting International Incorporation, Hsinchu, Taiwan; 2Certified Occupational Medicine Physician & Deputy Secretary General, Taiwan Environmental and Occupational Medicine Association, Tainan, Taiwan; 3Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan; 4Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 5Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 6Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan; 7Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 8Prospect Clinic for Otorhinolaryngology and Neurology, Kaohsiung, Taiwan; 9Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai’s Home, Kaohsiung, Taiwan; 10WinShine Clinics in Specialty of Psychiatry, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: Evidence has suggested that dysregulation of the dopaminergic system may play a significant role in the pathogenesis of attention-deficit/hyperactivity disorder (ADHD) in children. Manganese, a neurotoxicant, has been reported to exert its neurotoxicity by affecting the dopaminergic system. However, the association between peripheral manganese levels and ADHD has not been comprehensively reviewed. This study aimed to investigate the association between peripheral manganese levels and ADHD in children. An electronic search was performed on databases including PubMed, ProQuest, ClinicalKey, Cochrane Library, ClinicalTrials.gov, Embase, Web of Science, and ScienceDirect with last search on March 25th, 2018. As per the inclusion criteria, human observational studies investigating peripheral manganese levels in children with ADHD and controls were included. The meta-analysis was performed using a random-effects model, and possible confounders were examined by subgroup analysis. In total, four articles with 175 ADHD children and 999 controls were recruited. The manganese levels were significantly higher in ADHD children than in controls (p=0.033), when studies investigating blood levels and those investigating hair levels were included. However, when only studies investigating blood levels were included, there was no significant difference between ADHD children and controls (p=0.076). Our results support higher peripheral manganese levels in children diagnosed with ADHD than those in controls. Further primary studies are needed to clarify this association. Keywords: meta-analysis, manganese, ADHD, pediatric psychiatry, reviewShih JHZeng BYLin PYChen TYChen YWWu CKTseng PTWu MKDove Medical Pressarticlemeta-analysismanganeseADHDpediatric psychiatryreviewNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1831-1842 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	meta-analysis manganese ADHD pediatric psychiatry review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	meta-analysis manganese ADHD pediatric psychiatry review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shih JH Zeng BY Lin PY Chen TY Chen YW Wu CK Tseng PT Wu MK Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
description	Jun-Hao Shih,1,2,* Bing-Yan Zeng,3,* Pao-Yen Lin,4,5 Tien-Yu Chen,6,7 Yen-Wen Chen,8 Ching-Kuan Wu,9 Ping-Tao Tseng,10 Ming-Kung Wu4 1Department of Occupational and Environmental Health Consultation, EMHA Consulting International Incorporation, Hsinchu, Taiwan; 2Certified Occupational Medicine Physician & Deputy Secretary General, Taiwan Environmental and Occupational Medicine Association, Tainan, Taiwan; 3Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan; 4Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 5Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; 6Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan; 7Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan; 8Prospect Clinic for Otorhinolaryngology and Neurology, Kaohsiung, Taiwan; 9Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai’s Home, Kaohsiung, Taiwan; 10WinShine Clinics in Specialty of Psychiatry, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: Evidence has suggested that dysregulation of the dopaminergic system may play a significant role in the pathogenesis of attention-deficit/hyperactivity disorder (ADHD) in children. Manganese, a neurotoxicant, has been reported to exert its neurotoxicity by affecting the dopaminergic system. However, the association between peripheral manganese levels and ADHD has not been comprehensively reviewed. This study aimed to investigate the association between peripheral manganese levels and ADHD in children. An electronic search was performed on databases including PubMed, ProQuest, ClinicalKey, Cochrane Library, ClinicalTrials.gov, Embase, Web of Science, and ScienceDirect with last search on March 25th, 2018. As per the inclusion criteria, human observational studies investigating peripheral manganese levels in children with ADHD and controls were included. The meta-analysis was performed using a random-effects model, and possible confounders were examined by subgroup analysis. In total, four articles with 175 ADHD children and 999 controls were recruited. The manganese levels were significantly higher in ADHD children than in controls (p=0.033), when studies investigating blood levels and those investigating hair levels were included. However, when only studies investigating blood levels were included, there was no significant difference between ADHD children and controls (p=0.076). Our results support higher peripheral manganese levels in children diagnosed with ADHD than those in controls. Further primary studies are needed to clarify this association. Keywords: meta-analysis, manganese, ADHD, pediatric psychiatry, review
format	article
author	Shih JH Zeng BY Lin PY Chen TY Chen YW Wu CK Tseng PT Wu MK
author_facet	Shih JH Zeng BY Lin PY Chen TY Chen YW Wu CK Tseng PT Wu MK
author_sort	Shih JH
title	Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
title_short	Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
title_full	Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
title_fullStr	Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
title_full_unstemmed	Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
title_sort	association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5aba34a03c1442acae807157c2273002
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Association between peripheral manganese levels and attention-deficit/hyperactivity disorder: a preliminary meta-analysis

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